Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi'an 710069, Shaanxi, China.
Clinical Laboratory, Xi'an 630 Hospital, Yanliang, Xi'an 710089, Shaanxi, China.
Curr Mol Med. 2020;20(5):379-387. doi: 10.2174/1566524019666191025091204.
Esophageal cancer (EC) is the sixth leading cause of cancer death worldwide, and the overall incidence is increasing.
The aim of this study was to evaluate the association between single nucleotide polymorphisms in IL1R2 and EC risk in the Chinese population.
Genotyping of six SNPs of IL1R2 was performed with the Agena MassARRAY platform from 384 EC and 499 controls. The association between polymorphisms and EC risk was assessed by performing genetics models and haplotype analyses.
Overall analysis results showed that the allele C of rs11674595 (odds ratio [OR] = 1.42, 95% confidence interval [CI]: 1.14-1.77, p = 0.002) and allele G of rs2072472 (allele: OR = 1.35, 95% CI: 1.08-1.69, p = 0.008) were associated with an increased EC risk. The rs11674595 and rs2072472 were found to be correlated with EC risk under the codominant, dominant, and additive models. Stratification analysis found that rs11674595 and rs2072472 were associated with increased EC risk in male and in age > 55 years old subgroup. In addition, Crs11674595Grs4851527 haplotype was significantly associated with 1.44-fold increased risk of EC (95% CI: 1.12-1.84, p = 0.004).
Our results reveal the significant association between SNPs (rs11674595 and rs2072472) in the IL1R2 and EC risk in the Chinese Han population. The findings may provide meaningful reference for the prevention and treatment of EC.
食管癌（EC）是全球第六大癌症死亡原因，总体发病率呈上升趋势。
本研究旨在评估白细胞介素 1 受体 2（IL1R2）中的单核苷酸多态性与中国人群 EC 风险之间的关系。
采用 Agena MassARRAY 平台对 384 例 EC 患者和 499 例对照者的 IL1R2 中的 6 个 SNP 进行基因分型。通过遗传模型和单倍型分析评估多态性与 EC 风险之间的关系。
总体分析结果显示，rs11674595 等位基因 C（比值比[OR] = 1.42，95%置信区间[CI]：1.14-1.77，p = 0.002）和 rs2072472 等位基因 G（等位基因：OR = 1.35，95%CI：1.08-1.69，p = 0.008）与 EC 风险增加相关。rs11674595 和 rs2072472 在共显性、显性和加性模型下均与 EC 风险相关。分层分析发现，rs11674595 和 rs2072472 与男性和年龄>55 岁亚组 EC 风险增加相关。此外，rs11674595Grs4851527 单倍型与 EC 风险增加显著相关（OR = 1.44，95%CI：1.12-1.84，p = 0.004）。
本研究结果表明，IL1R2 中的 SNP（rs11674595 和 rs2072472）与中国汉族人群 EC 风险显著相关。这些发现可能为 EC 的预防和治疗提供有意义的参考。
