Department of Integrated Traditional and Western medicine, Xi'an Chest Hospital, Xi'an, Shaanxi, China.
Department of Rehabilitation Medicine, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China.
J Gene Med. 2018 Oct;20(10-11):e3057. doi: 10.1002/jgm.3057. Epub 2018 Oct 18.
Interleukin (IL)-1 has been reported to be involved in the development of tuberculosis (TB). IL1R1 and IL1R2 encode a cytokine receptor that belongs to the IL-1 receptor family. However, few studies have reported on the polymorphisms of IL1R1 and IL1R2 in TB patients.
We investigated nine single-nucleotide polymorphisms (SNPs) in IL1R1 and IL1R2 in 300 TB patients and 300 controls, aiming to evaluate their association with TB risk. Odds ratios and 95% confidence intervals were calculated using unconditional logistic regression after adjusting for age and gender.
On comparing the allele frequencies of candidate SNPs, we found that the minor allele 'A' of rs4851527 in IL1R2 was associated with a decreased risk of TB, whereas the minor alleles of rs10490571, rs956730 and rs3917225 in IL1R1 were associated with an increased risk of TB (p < 0.05). In the genetic model analysis, we found that the allele 'A' of rs4851527 was correlated with a decreased risk of TB in a log-additive model, whereas the minor alleles of rs719250, rs3218977, rs10490571, rs956730 and rs3917225 were correlated with an increased risk of TB in dominant and log-additive models (p < 0.05). Additionally, we found three haplotypes that were associated with an increased risk of TB: TGCT and TGTT haplotypes constructed by rs11674595, rs4851527, rs719250 and rs3218896, as well as GA haplotype constructed by rs3218977 and rs2072472 (p < 0.05).
Our data shed new light on the association between genetic polymorphisms of IL1R1 and IL1R2 and TB susceptibility in the Chinese Han population.
白细胞介素 (IL)-1 已被报道参与结核病 (TB) 的发展。IL1R1 和 IL1R2 编码细胞因子受体，属于 IL-1 受体家族。然而，很少有研究报道 IL1R1 和 IL1R2 的多态性与 TB 患者之间的关系。
我们研究了 300 例 TB 患者和 300 例对照者中 IL1R1 和 IL1R2 的 9 个单核苷酸多态性 (SNP)，旨在评估它们与 TB 风险的关联。调整年龄和性别后，使用无条件逻辑回归计算比值比和 95%置信区间。
在比较候选 SNP 的等位基因频率时，我们发现 IL1R2 中的 rs4851527 的次要等位基因 'A' 与 TB 风险降低相关，而 IL1R1 中的 rs10490571、rs956730 和 rs3917225 的次要等位基因与 TB 风险增加相关（p<0.05）。在遗传模型分析中，我们发现 rs4851527 的等位基因 'A' 在加性模型中与 TB 风险降低相关，而 rs719250、rs3218977、rs10490571、rs956730 和 rs3917225 的次要等位基因在显性和加性模型中与 TB 风险增加相关（p<0.05）。此外，我们发现三个与 TB 风险增加相关的单倍型：由 rs11674595、rs4851527、rs719250 和 rs3218896 构建的 TGCT 和 TGTT 单倍型，以及由 rs3218977 和 rs2072472 构建的 GA 单倍型（p<0.05）。
我们的数据为中国汉族人群中 IL1R1 和 IL1R2 的遗传多态性与 TB 易感性之间的关系提供了新的见解。
