The Impacts of and Genetic Variants on Rheumatoid Arthritis Risk in the Chinese Han Population: A Case-Control Study.

BACKGROUND

Rheumatoid arthritis (RA), an autoimmune systemic inflammatory disease, largely resulted from genetic factor. Our purpose was to explore the association for and genetic variants with RA susceptibility in the Chinese Han population.

PATIENTS AND METHODS

A total of 508 RA patients and 494 controls were involved in this case-control study; single-nucleotide polymorphisms (SNPs) genotyping was identified by the Agena MassARRAY platform. The relationship between polymorphisms and RA susceptibility was calculated using the Pearson's Chi-square test with odds ratios and 95% confidence intervals (CIs) in multiple genetic models. The Pearson's Chi-square test and Student's -test were used for sample basic characteristic analysis. And linkage disequilibrium (LD) analysis and haplotype analysis were performed by logistic regression analysis.

RESULTS

The result from this study showed that rs2072472 () was an increased risk factor of RA (adjusted OR = 1.41, = 0.011). Stratified analysis indicated SNPs rs10490571, rs956730, rs3917318 of , and SNPs rs4851527, rs719250, rs3218896, rs3218977, rs2072472 of had impacts on RA risk after stratification based on gender and average age (54 years). Finally, haplotype analysis revealed that AA haplotype in was related to a decreased RA risk (adjusted OR = 0.79; 95% CI = 0.65-0.94; = 0.010). Yet, rs3917225() and rs11674595() were not significant in RA association analysis.

CONCLUSION

We determined SNPs (rs3917318, rs956730, rs1049057) of and SNPs (rs3218977, rs719250, rs4851527, rs3218896, rs2072472) of were correlated with the RA susceptibility in the Chinese Han population.