Bodden Carina, Hannan Anthony J, Reichelt Amy C
The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, 3010 VIC, Australia.
The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, 3010 VIC, Australia; Department of Anatomy and Neuroscience, University of Melbourne, Melbourne, 3010 VIC, Australia.
Trends Endocrinol Metab. 2020 Feb;31(2):131-149. doi: 10.1016/j.tem.2019.10.005. Epub 2019 Nov 16.
Globally, obesity has reached epidemic proportions. The rapidly increasing numbers of overweight people can be traced back to overconsumption of energy-dense, poor-quality foods as well as physical inactivity. This development has far-reaching and costly implications. Not only is obesity associated with serious physiological and psychological complications, but mounting evidence also indicates a ripple effect through generations via epigenetic changes. Parental obesity could induce intergenerational and transgenerational changes in metabolic and brain function of the offspring. Most research has focused on maternal epigenetic and gestational effects; however, paternal contributions are likely to be substantial. We focus on the latest advances in understanding the mechanisms of epigenetic inheritance of obesity-evoked metabolic and neurobiological changes through the paternal germline that predict wide-ranging consequences for the following generation(s).
在全球范围内，肥胖已达到流行程度。超重人数的迅速增加可追溯到高能量、低质量食物的过度消费以及身体活动不足。这一发展产生了深远且代价高昂的影响。肥胖不仅与严重的生理和心理并发症相关，而且越来越多的证据还表明，肥胖会通过表观遗传变化在几代人之间产生连锁反应。父母肥胖可能会导致后代代谢和脑功能的代际及跨代变化。大多数研究都集中在母体表观遗传和孕期影响上；然而，父体的影响可能也很大。我们关注的是在理解肥胖引发的代谢和神经生物学变化通过父系生殖细胞进行表观遗传遗传机制方面的最新进展，这些变化预示着对后代会产生广泛的影响。
