Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.
Anchor Biomed Research Institute, Ogbomoso, Oyo State, Nigeria.
Mol Biol Rep. 2024 Aug 1;51(1):881. doi: 10.1007/s11033-024-09823-9.
Epigenetics studies gene expression changes influenced by environmental and lifestyle factors, linked to health conditions like reproductive aging. Male reproductive aging causes sperm decline, conceiving difficulties, and increased genetic abnormalities. Recent research focuses on epigenetics' role in male reproductive aging.
This review explores epigenetics and male reproductive aging, focusing on sperm quality, environmental and lifestyle factors' impact, and potential health implications for offspring.
An extensive search of the literature was performed applying multiple databases, such as PubMed and Google Scholar. The search phrases employed were: epigenetics, male reproductive ageing, sperm quality, sperm quantity, environmental influences, lifestyle factors, and offspring health. This review only included articles that were published in English and had undergone a peer-review process. The literature evaluation uncovered that epigenetic alterations have a substantial influence on the process of male reproductive ageing.
Research has demonstrated that variations in the quality and quantity of sperm that occur with ageing are linked to adjustments in DNA methylation and histone. Moreover, there is evidence linking epigenetic alterations in sperm to environmental and lifestyle factors, including smoking, alcohol intake, and exposure to contaminants. These alterations can have enduring impacts on the well-being of descendants, since they can shape the activation of genes and potentially elevate the likelihood of genetic disorders. In conclusion, epigenetics significantly influences male reproductive aging, with sperm quality and quantity influenced by environmental and lifestyle factors.
This underscores the need for comprehensive approaches to managing male reproductive health, and underscores the importance of considering epigenetics in diagnosis and treatment.
表观遗传学研究受环境和生活方式因素影响的基因表达变化，这些变化与生殖衰老等健康状况有关。男性生殖衰老导致精子数量下降、受孕困难和遗传异常增加。最近的研究集中在表观遗传学在男性生殖衰老中的作用。
本综述探讨了表观遗传学与男性生殖衰老，重点关注精子质量、环境和生活方式因素的影响，以及对后代潜在的健康影响。
通过使用PubMed 和 Google Scholar 等多个数据库，对文献进行了广泛的搜索。使用的搜索词是：表观遗传学、男性生殖衰老、精子质量、精子数量、环境影响、生活方式因素和后代健康。本综述仅包括以英文发表并经过同行评审的文章。文献评估表明，表观遗传改变对男性生殖衰老过程有重大影响。
研究表明，随着年龄的增长，精子质量和数量的变化与 DNA 甲基化和组蛋白的变化有关。此外，有证据表明，精子中的表观遗传改变与环境和生活方式因素有关，包括吸烟、饮酒和接触污染物。这些改变可能对后代的健康产生持久的影响，因为它们可以塑造基因的激活，并可能增加遗传疾病的可能性。总之，表观遗传学对男性生殖衰老有重要影响，精子质量和数量受环境和生活方式因素的影响。
这凸显了全面管理男性生殖健康的必要性，并强调了在诊断和治疗中考虑表观遗传学的重要性。
