Gupta Harsh V, Zhang Nan, Driver-Dunckley Erika, Mehta Shyamal H, Beach Thomas G, Adler Charles H
Department of Neurology Mayo Clinic College of Medicine Scottsdale Arizona USA.
Department of Biostatistics Mayo Clinic Scottsdale Arizona USA.
Mov Disord Clin Pract. 2019 Sep 6;6(8):672-677. doi: 10.1002/mdc3.12821. eCollection 2019 Nov.
Abnormal color vision and contrast acuity may have significant impact on daily activities.
Evaluate color visual acuity, at high and low contrast, in Parkinson's disease (PD) and controls using an iPad application.
Color visual acuity was tested with the Variable Contrast Acuity Chart (King-Devick Test LLC, Oakbrook Terrace, IL) on an iPad 2 at 40 cms using five colors (red, green, blue, yellow, and black) at low (2.5%) and high (100%) contrast. A numerical score (0-95) was assigned based on the number of correctly identified letters.
Thirty-six PD (mean ± standard deviation age 68 ± 10 years) and 36 controls (72 ± 11.2 years) were studied. PD disease duration was 6.4 ± 4.6 years; MDS-UPDRS part II was 11.7 ± 7.0, and part III was 24.5 ± 9.9. After adjusting for age and sex, PD patients had significantly ( < 0.05) lower scores at high (100%) as well as low (2.5%) contrast for all five colors tested (red, green, blue, yellow, and black), except yellow low contrast (2.5%; = 0.10). The largest effect size (0.88) was with yellow high contrast, and the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy using a cut-off score of 82 was 31%, 97%, 92%, 58%, and 64%, respectively. No correlation to disease duration was found.
This iPad application may be a simple-to-use biomarker for assessing color vision in PD. Further research is needed to determine disease specificity and whether there is a role in monitoring disease progression, treatment response, and identifying prodromal PD.
异常色觉和对比敏感度可能对日常活动产生重大影响。
使用一款iPad应用程序评估帕金森病（PD）患者和对照组在高对比度和低对比度下的颜色视力。
使用可变对比度视力表（King-Devick Test LLC，伊利诺伊州橡树溪台地）在iPad 2上于40厘米处测试颜色视力，测试五种颜色（红色、绿色、蓝色、黄色和黑色）在低对比度（2.5%）和高对比度（100%）下的情况。根据正确识别字母的数量给出一个数值评分（0 - 95）。
研究了36名帕金森病患者（平均年龄±标准差为68 ± 10岁）和36名对照组（72 ± 11.2岁）。帕金森病病程为6.4 ± 4.6年；MDS-UPDRS第二部分评分为11.7 ± 7.0，第三部分评分为24.5 ± 9.9。在对年龄和性别进行校正后，除黄色低对比度（2.5%；P = 0.10）外，帕金森病患者在所有测试的五种颜色（红色、绿色、蓝色、黄色和黑色）的高对比度（100%）和低对比度（2.5%）下得分均显著更低（P < 0.05）。最大效应量（0.88）出现在黄色高对比度时，使用截断分数82时的敏感度、特异度、阳性预测值、阴性预测值和准确率分别为31%、97%、92%、58%和64%。未发现与病程相关。
这款iPad应用程序可能是一种用于评估帕金森病患者色觉的易于使用的生物标志物。需要进一步研究以确定疾病特异性以及其在监测疾病进展、治疗反应和识别前驱期帕金森病方面是否有作用。
