Department of Ophthalmology, Japan Community Healthcare Organization Chukyo Hospital, Nagoya, Japan.
Chukyo Eye Clinic, Nagoya, Japan.
PLoS One. 2021 Nov 29;16(11):e0260525. doi: 10.1371/journal.pone.0260525. eCollection 2021.
To evaluate the age-related change in color visual acuity (CVA) in normal eyes.
In total, 162 normal eyes (162 subjects, women: 52, men: 110, age range: 15-68 years) with best-corrected visual acuity (BCVA) ≥20/13 were enrolled. Fifteen colors from the New Color Test (chroma 6) were applied to Landolt "C" rings, white point D65 was applied as background, and a luminance of 30 cd/m2 was set for both the rings and the background. These rings were used to measure the chromatic spatial discrimination acuity as the CVA value, while changing the stimulus size. Correlations of the CVA value of each color and age were evaluated. Mean CVA values of all 15 colors (logarithm of the minimum angle of resolution) were compared between age groups in 10-year increments.
Nine CVA values (red, yellow-red, red-yellow, green, blue-green, green-blue, purple, red-purple, and purple-red) were negatively correlated with age (all p<0.05); the remaining six (yellow, green-yellow, yellow-green, blue, purple-blue, and blue-purple), as well as BCVA were not. The age groups with the best to worst mean CVA values of 15 colors were as follows: 20-29 (mean ± standard deviation, 0.303 ± 0.113), 30-39 (0.324 ± 0.096), 10-19 (0.333 ± 0.022), 50-59 (0.335 ± 0.078), 40-49 (0.339 ± 0.096), and 60-69 (0.379 ± 0.125) years. There were statistically significant differences between mean CVA values of the following groups: 20-29 and 40-49 years; 20-29 and 60-69 years; 30-39 and 60-69 years (all p<0.01).
The CVA values related to the medium/long-wavelength-sensitive cones were more susceptible to aging than those related to the short-wavelength-sensitive cones. This differed from previous reports, and may be related to the difference in the range of foveal cone function evaluated with each examination.
评估正常眼中年龄相关的颜色视力（CVA）变化。
共纳入 162 只正常眼（162 例，女性 52 例，男性 110 例，年龄范围 15-68 岁），最佳矫正视力（BCVA）≥20/13。使用新颜色测试（色度 6）的 15 种颜色应用于 Landolt“C”环，以白色点 D65 作为背景，环和背景的亮度均设置为 30 cd/m2。这些环用于测量色觉空间辨别力作为 CVA 值，同时改变刺激大小。评估每种颜色的 CVA 值与年龄的相关性。比较每组年龄 10 年的 15 种颜色的平均 CVA 值（最小分辨率角度的对数）。
9 种 CVA 值（红、红黄、红-黄、绿、绿-蓝、绿-蓝、紫、红-紫、紫-红）与年龄呈负相关（均 p<0.05）；其余六种（黄、绿-黄、黄-绿、蓝、蓝-紫、蓝-紫）以及 BCVA 则没有。15 种颜色中 CVA 值最佳到最差的年龄组如下：20-29 岁（平均±标准差，0.303±0.113）、30-39 岁（0.324±0.096）、10-19 岁（0.333±0.022）、50-59 岁（0.335±0.078）、40-49 岁（0.339±0.096）和 60-69 岁（0.379±0.125）。以下组之间的平均 CVA 值存在统计学差异：20-29 岁和 40-49 岁；20-29 岁和 60-69 岁；30-39 岁和 60-69 岁（均 p<0.01）。
与短波长敏感锥体相关的 CVA 值比与中/长波长敏感锥体相关的 CVA 值更容易受到年龄的影响。这与以前的报告不同，可能与每次检查评估的黄斑锥体功能范围不同有关。
