Department of Periodontology and Operative Dentistry, Faculty of Dentistry, University Hospital Münster, Münster, Germany.
Department of Orthodontics and Dentofacial Orthopedics, Dental School/Medical Faculty, University of Bern, Bern, Switzerland.
J Clin Periodontol. 2020 Feb;47(2):257-266. doi: 10.1111/jcpe.13222. Epub 2019 Dec 11.
To assess the reporting and handling of incomplete outcome data in randomized clinical trials (RCTs) published in implant dentistry.
We included RCTs on interventions related to the treatment with dental implants and presented any form of missing data. PubMed, SCOPUS and Cochrane databases were searched for studies published between May 2015 and May 2018. Reporting and handling of missing data at the study level were evaluated using a series of relevant questions. Descriptive data were reported, and univariable analyses were performed to evaluate the association of study variables with quality of reporting and data handling.
One-hundred and thirty-seven RCT reports were included from the 7,116 initially retrieved publications. The reporting of incomplete outcome data varied greatly among the trials and for the different questions. The range of adequately reported questions was between 3.64% (question: comparison of baseline characteristics of all randomised participants) and 100% (question: explicit reporting of missing data). The complete case analysis was the most used (45.3%) approach for incomplete outcome data handling.
Randomized studies in implant dentistry have room for improvement in both the reporting and the handling of incomplete outcome data.
评估发表在种植牙领域的随机临床试验（RCT）中不完整结局数据的报告和处理情况。
我们纳入了与种植牙治疗相关的干预措施的 RCT，并报告了任何形式的缺失数据。在 2015 年 5 月至 2018 年 5 月期间，我们在 PubMed、SCOPUS 和 Cochrane 数据库中检索了相关研究。使用一系列相关问题评估了研究层面缺失数据的报告和处理情况。报告了描述性数据，并进行了单变量分析，以评估研究变量与报告和数据处理质量的关联。
从最初检索到的 7116 篇文献中，共纳入了 137 篇 RCT 报告。不同试验和不同问题的不完整结局数据报告差异很大。充分报告的问题范围在 3.64%（问题：所有随机参与者基线特征的比较）到 100%（问题：缺失数据的明确报告）之间。完全案例分析是最常用的（45.3%）处理不完整结局数据的方法。
种植牙领域的随机研究在不完整结局数据的报告和处理方面仍有改进空间。
