光控超分子纳米片的可逆二级自组装及其药物传递行为。
Photo-controlled reversible secondary self-assembly of supramolecular nanosheets and their drug delivery behavior.
机构信息
MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, P. O. Box 1254, Harbin, 150001, P. R. China.
出版信息
J Mater Chem B. 2019 Dec 11;7(48):7736-7743. doi: 10.1039/c9tb02017a.
Supramolecular nano-drug delivery systems with stimuli-responsive features have attracted extensive attention in photodynamic therapy. In this work, a new kind of photo-controlled reversible two dimensional (2D) nanosheet was constructed by cucurbit[8]uril (CB[8])-mediated ternary complexation with lanthanide complexes, azobenzene quaternary ammonium salt and sodium dodecyl sulfonate, which exhibited rapid morphological transformation and high drug loading capacities. The constructed supramolecular secondary self-assembly system has become a very promising candidate as a drug nanocarrier.
具有刺激响应特性的超分子纳米药物递送系统在光动力治疗中引起了广泛关注。在这项工作中，通过葫芦[8]脲（CB[8]）介导的镧系配合物、偶氮苯季铵盐和十二烷基磺酸钠三元配合物，构建了一种新型的光控可逆二维（2D）纳米片，其具有快速的形态转变和高载药能力。构建的超分子二级自组装体系作为药物纳米载体具有很大的应用潜力。
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