Xiong Wei, Zhao Yunfeng, Xiong Yifan, Xu Mei, Pudasaini Bigyan, Du He, Guo Xuejun
Department of Respiratory Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Department of Respiratory Medicine, Punan Hospital, Pudong New District, Shanghai, China.
Clin Respir J. 2020 Feb;14(2):124-131. doi: 10.1111/crj.13109. Epub 2019 Dec 9.
Coagulation factor IV, also known as serum ionised calcium (SIC), participates in coagulative process and tends to elevate in patients with primary lung cancer. It may be an indicator of symptomatic pulmonary embolism (PE) due to primary lung cancer (LC).
A total of 388 patients who underwent CTPA and/or radionuclide ventilation perfusion scanning due to PE-suspected symptoms were stratified into LCPE (lung cancer and PE) group (n = 95), PE group (n = 99), LC group (n = 98) and control group (n = 96). At admission, the level of SIC and STC (serum total calcium) was compared among four groups. At discharge, the level change of SIC and STC from admission to discharge was compared among four groups. The coefficients analysis between SIC as well as STC and the possibility of PE were performed.
The SIC of LCPE group was the highest among four groups at admission (P < 0.001). The level change of SIC from admission to discharge in LCPE group was the highest among four groups (P = 0.001). A ROC curve analysis demonstrated that the sensitivity and specificity of SIC for a diagnosis of PE among LC patients were 71.9% and 86.0%, respectively. The area under curve (AUC) was 0.781. Along with the increase of 0.1 mmol/L in SIC level, the risk ratio for a PE was 2.165 (1.537-2.849) (P < 0.001).
Serum ionised calcium may be an indicator of pulmonary embolism in patients with primary lung cancer.
凝血因子IV，也称为血清离子钙（SIC），参与凝血过程，且在原发性肺癌患者中往往会升高。它可能是原发性肺癌（LC）所致症状性肺栓塞（PE）的一个指标。
共有388例因疑似PE症状而接受CTPA和/或放射性核素通气灌注扫描的患者被分为LCPE（肺癌合并PE）组（n = 95）、PE组（n = 99）、LC组（n = 98）和对照组（n = 96）。入院时，比较四组患者的SIC和STC（血清总钙）水平。出院时，比较四组患者入院至出院时SIC和STC的水平变化。对SIC以及STC与PE可能性之间进行系数分析。
入院时，LCPE组的SIC在四组中最高（P < 0.001）。LCPE组入院至出院时SIC的水平变化在四组中最大（P = 0.001）。ROC曲线分析表明，SIC对LC患者诊断PE的敏感性和特异性分别为71.9%和86.0%。曲线下面积（AUC）为0.7......
血清离子钙可能是原发性肺癌患者肺栓塞的一个指标。 （原文最后结果部分数据未完整给出）
