Xiong Wei, Zhao Yunfeng, Xu Mei, Guo Jian, Pudasaini Bigyan, Wu Xueling, Liu Jinming
Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Department of Respiratory Medicine, Punan Hospital, Pudong New District, Shanghai, China.
Oncotarget. 2017 Jun 20;8(25):41412-41421. doi: 10.18632/oncotarget.17916.
Tumor markers (TMs) and D-Dimer are both hallmarks of severity and prognosis of lung cancer. Tumor markers could be related to pulmonary embolism (PE) in lung cancer.
The number of abnormal tumor markers of lung cancer patients with pulmonary embolism (3.9 ± 1.1vs1.6 ± 0.6,P 0.005) was more than that in patients without pulmonary embolism. TMs panel (P trend < 0.001), CEA (R2 0.735, P0.003) and CYFRA21-1 (R2 0.718, P0.005) were positively correlated with D-Dimer in patients with pulmonary embolism. The multivariate logistic regression analysis showed that, for tumor markers, TMs panel (OR5.98, P < 0.001) had the strongest correlation with pulmonary embolism. The AUC (area under curve) of TMs panel and CEA were 0.82 [95%CI (0.71-0.95), P < 0.001] and 0.71 [95%CI (0.62-0.84), P 0.002] by ROC (receiver operating characteristic) curve analysis, respectively.
Tumor markers were compared between lung cancer patients complicated with pulmonary embolism and those without pulmonary embolism Then the correlation between each tumor marker as well as panel of combined TMs and D-Dimer as well as pulmonary embolism were analyzed for patients with pulmonary embolism.
There is a relationship between tumor markers and pulmonary embolism in patients with lung cancer. The panel of combined tumor markers is a valuable diagnostic marker for pulmonary embolism in lung cancer.
肿瘤标志物（TMs）和D-二聚体都是肺癌严重程度和预后的标志。肿瘤标志物可能与肺癌中的肺栓塞（PE）有关。
合并肺栓塞的肺癌患者异常肿瘤标志物数量（3.9±1.1对1.6±0.6，P<0.005）多于未合并肺栓塞的患者。在合并肺栓塞的患者中，肿瘤标志物组合（P趋势<0.001）、癌胚抗原（CEA）（R²=0.735，P=0.003）和细胞角蛋白19片段（CYFRA21-1）（R²=0.718，P=0.005）与D-二聚体呈正相关。多因素逻辑回归分析显示，对于肿瘤标志物，肿瘤标志物组合（OR=5.98，P<0.001）与肺栓塞的相关性最强。通过受试者工作特征（ROC）曲线分析，肿瘤标志物组合和CEA的曲线下面积（AUC）分别为0.82[95%可信区间（CI）（0.71-0.95），P<0.001]和0.71[95%CI（0.62-0.84），P=0.002]。
比较合并肺栓塞和未合并肺栓塞的肺癌患者的肿瘤标志物。然后分析合并肺栓塞患者中各肿瘤标志物以及肿瘤标志物组合与D-二聚体和肺栓塞之间的相关性。
肺癌患者的肿瘤标志物与肺栓塞之间存在关联。肿瘤标志物组合是肺癌中肺栓塞的有价值诊断标志物。
