The Department of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, China.
J Biomater Sci Polym Ed. 2020 Feb;31(3):407-422. doi: 10.1080/09205063.2019.1696004. Epub 2019 Dec 3.
Polyurethane (PU) and polyurea (PUA) materials have shown significant potential for application in tissue repair. Herein, we design a glycerol ethoxylate (PEG)-based poly(urethane-urea) for bone tissue repair. The polymer precursor was prepared from the reaction of PEG and isophorone diisocyanate (IPDI). The cystine dimethyl ester was used as a cross-linker for the preparation of poly(urethane-urea) elastomers. The material was further strengthened by physical blending of nano-hydroxyapatite (nHA). The physical and biological properties of final material were evaluated by mechanical testing, scanning electron microscopy characterization, degradation tests, cell proliferation and cell differentiation assays. The obtained scaffolds showed good mechanical strength, excellent biocompatibility and osteogenic capability. All the evidences demonstrated that this type of materials has good prospects for bone tissue repair application.
聚氨酯（PU）和聚脲（PUA）材料在组织修复方面具有重要的应用潜力。本文设计了一种基于甘油乙氧基化物（PEG）的聚（聚氨酯-脲）用于骨组织修复。聚合物前体是由 PEG 和异佛尔酮二异氰酸酯（IPDI）反应制备的。胱氨酸二甲酯作为交联剂用于制备聚（聚氨酯-脲）弹性体。最后，通过纳米羟基磷灰石（nHA）的物理共混进一步增强了材料。通过机械测试、扫描电子显微镜表征、降解试验、细胞增殖和细胞分化试验对最终材料的物理和生物学性能进行了评估。得到的支架具有良好的机械强度、优异的生物相容性和成骨能力。所有证据表明，这种材料在骨组织修复应用方面具有良好的应用前景。
