从日本东海地区猪分离出的猪链球菌菌株的抗菌药物耐药表型和基因型变化
Changes in antimicrobial resistance phenotypes and genotypes in Streptococcus suis strains isolated from pigs in the Tokai area of Japan.
作者信息
Ichikawa Takashi, Oshima Masaaki, Yamagishi Junjiro, Muramatsu Chieko, Asai Tetsuo
机构信息
Nagoya City Meat Hygiene Inspection Laboratory, 1-39 Funami-cho, Minato-ku, Nagoya, Aichi 455-0027, Japan.
Present address: Nagoya City Public Health Research Institute, 2266-132 Anagahora, Shimoshidami, Moriyama-ku, Nagoya, Aichi 463-0003, Japan.
出版信息
J Vet Med Sci. 2020 Jan 10;82(1):9-13. doi: 10.1292/jvms.19-0449. Epub 2019 Nov 21.
Streptococcus suis strains isolated from porcine endocarditis and tonsils in the Tokai area of Japan during 2004-2007 and 2014-2016 (n=114) were tested for antimicrobial susceptibility and distribution of selected resistance genes. No strains showed resistance to penicillin, ampicillin, cefotaxime, meropenem, vancomycin, and levofloxacin. High resistance to tetracycline (80.7%), clindamycin (65.8%), erythromycin (56.1%), and clarithromycin (56.1%) was observed. In chloramphenicol and sulfamethoxazole-trimethoprim, there was a trend towards increased resistance between the first (2004-2007) and second (2014-2016) periods. tet(O) and erm(B) genes were the most frequently detected, and tet(M) and mef(A/E) genes were only detected in strains isolated during 2014-2016. These results indicate that chloramphenicol and sulfamethoxazole-trimethoprim resistance, and tet(M) and mef(A/E) genes emerged in S. suis of this area after 2014.
对2004 - 2007年以及2014 - 2016年期间从日本东海地区猪心内膜炎和扁桃体中分离出的猪链球菌菌株（n = 114）进行了药敏试验以及特定耐药基因分布检测。没有菌株对青霉素、氨苄西林、头孢噻肟、美罗培南、万古霉素和左氧氟沙星耐药。观察到对四环素（80.7%）、克林霉素（65.8%）、红霉素（56.1%）和克拉霉素（56.1%）的高耐药性。在氯霉素和磺胺甲恶唑 - 甲氧苄啶方面，在第一个时期（2004 - 2007年）和第二个时期（2014 - 2016年）之间存在耐药性增加的趋势。tet(O)和erm(B)基因是最常检测到的，而tet(M)和mef(A/E)基因仅在2014 - 2016年分离出的菌株中检测到。这些结果表明，2014年后该地区猪链球菌中出现了对氯霉素和磺胺甲恶唑 - 甲氧苄啶的耐药性以及tet(M)和mef(A/E)基因。
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