传染性内源性逆转录病毒在杂种猫和纯种猫中的分布。

Distribution of infectious endogenous retroviruses in mixed-breed and purebred cats.

机构信息

Laboratory of Molecular Immunology and Infectious Disease, The United Graduate School of Veterinary Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, 753-8515, Japan.

Veterinary Diagnostic Laboratory, Marupi Lifetech Co., Ltd., 103 Fushiocho, Ikeda, Osaka, 563-0011, Japan.

出版信息

Arch Virol. 2020 Jan;165(1):157-167. doi: 10.1007/s00705-019-04454-z. Epub 2019 Nov 20.

DOI:10.1007/s00705-019-04454-z

PMID:31748876

Abstract

Endogenous retroviruses of domestic cats (ERV-DCs) are members of the genus Gammaretrovirus that infect domestic cats (Felis silvestris catus). Uniquely, domestic cats harbor replication-competent proviruses such as ERV-DC10 (ERV-DC18) and ERV-DC14 (xenotropic and nonecotropic viruses, respectively). The purpose of this study was to assess invasion by two distinct infectious ERV-DCs, ERV-DC10 and ERV-DC14, in domestic cats. Of a total sample of 1646 cats, 568 animals (34.5%) were positive for ERV-DC10 (heterozygous: 377; homozygous: 191), 68 animals (4.1%) were positive for ERV-DC14 (heterozygous: 67; homozygous: 1), and 10 animals (0.6%) were positive for both ERV-DC10 and ERV-DC14. ERV-DC10 and ERV-DC14 were detected in domestic cats in Japan as well as in Tanzania, Sri Lanka, Vietnam, South Korea and Spain. Breeding cats, including Singapura, Norwegian Forest and Ragdoll cats, showed high frequencies of ERV-DC10 (60-100%). By contrast, ERV-DC14 was detected at low frequency in breeding cats. Our results suggest that ERV-DC10 is widely distributed while ERV-DC14 is maintained in a minor population of cats. Thus, ERV-DC10 and ERV-DC14 have invaded cat populations independently.

摘要

家猫内源性逆转录病毒（ERV-DC）是感染家猫（Felis silvestris catus）的γ逆转录病毒属的成员。独特的是，家猫携带有复制能力的前病毒，如 ERV-DC10（ERV-DC18）和 ERV-DC14（分别为异嗜性和非嗜性病毒）。本研究旨在评估两种不同传染性 ERV-DC（ERV-DC10 和 ERV-DC14）在家猫中的入侵情况。在总共 1646 只猫的样本中，有 568 只动物（34.5%）对 ERV-DC10 呈阳性（杂合子：377；纯合子：191），68 只动物（4.1%）对 ERV-DC14 呈阳性（杂合子：67；纯合子：1），10 只动物（0.6%）对 ERV-DC10 和 ERV-DC14 均呈阳性。在日本以及坦桑尼亚、斯里兰卡、越南、韩国和西班牙的家猫中检测到了 ERV-DC10 和 ERV-DC14。繁殖猫，包括新加坡猫、挪威森林猫和布偶猫，显示出 ERV-DC10 的高频率（60-100%）。相比之下，繁殖猫中 ERV-DC14 的检出率较低。我们的结果表明，ERV-DC10 广泛分布，而 ERV-DC14 则在猫的少数种群中维持。因此，ERV-DC10 和 ERV-DC14 独立地入侵了猫种群。