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USP47-mediated deubiquitination and stabilization of YAP contributes to the progression of colorectal cancer.

作者信息

Pan Beiqing, Yang Yi, Li Jian, Wang Yu, Fang Chuantao, Yu Fa-Xing, Xu Yanhui

机构信息

Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Key Laboratory of Medical Epigenetics and Metabolism, Shanghai Medical College of Fudan University, Shanghai, 200032, China.

Children's Hospital and Institutes of Biomedical Sciences, Key Laboratory of Medical Epigenetics and Metabolism, Fudan University, Shanghai, 200032, China.

出版信息

Protein Cell. 2020 Feb;11(2):138-143. doi: 10.1007/s13238-019-00674-w.

DOI:10.1007/s13238-019-00674-w
PMID:31748975
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6954888/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2675/6954932/a09e9a2c0440/13238_2019_674_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2675/6954932/c0c60b8f2497/13238_2019_674_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2675/6954932/a09e9a2c0440/13238_2019_674_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2675/6954932/c0c60b8f2497/13238_2019_674_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2675/6954932/a09e9a2c0440/13238_2019_674_Fig2_HTML.jpg

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Mol Cell. 2019 Jan 3;73(1):7-21.e7. doi: 10.1016/j.molcel.2018.10.030. Epub 2018 Nov 21.
2
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Nat Commun. 2018 Jun 11;9(1):2269. doi: 10.1038/s41467-018-04620-y.
3
USP7 inhibitor P5091 inhibits Wnt signaling and colorectal tumor growth.
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Cancer Cell Int. 2025 Apr 26;25(1):164. doi: 10.1186/s12935-025-03796-w.
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The Role of Yes-Associated Protein in Inflammatory Diseases and Cancer.Yes相关蛋白在炎症性疾病和癌症中的作用。
MedComm (2020). 2025 Mar 10;6(3):e70128. doi: 10.1002/mco2.70128. eCollection 2025 Mar.
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An inherited predisposition allele promotes gastric cancer via enhancing deubiquitination-mediated activation of epithelial-to-mesenchymal transition signaling.一种遗传性易患性等位基因通过增强去泛素化介导的上皮-间质转化信号激活来促进胃癌发生。
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