Peng Na, Liu Jingwei, Hai Shuangshuang, Liu Yihong, Zhao Haibo, Liu Weixin
Department of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China.
Department of Anus and Intestine Surgery, The First Affiliated Hospital of China Medical University, Shenyang 110001, China.
Cancers (Basel). 2024 Feb 3;16(3):652. doi: 10.3390/cancers16030652.
Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive tract. CRC metastasis is a multi-step process with various factors involved, including genetic and epigenetic regulations, which turn out to be a serious threat to CRC patients. Post-translational modifications (PTMs) of proteins involve the addition of chemical groups, sugars, or proteins to specific residues, which fine-tunes a protein's stability, localization, or interactions to orchestrate complicated biological processes. An increasing number of recent studies suggest that dysregulation of PTMs, such as phosphorylation, ubiquitination, and glycosylation, play pivotal roles in the CRC metastasis cascade. Here, we summarized recent advances in the role of post-translational modifications in diverse aspects of CRC metastasis and its detailed molecular mechanisms. Moreover, advances in drugs targeting PTMs and their cooperation with other anti-cancer drugs, which might provide novel targets for CRC treatment and improve therapeutic efficacy, were also discussed.
结直肠癌（CRC）是消化道最常见的恶性肿瘤之一。CRC转移是一个涉及多种因素的多步骤过程，包括遗传和表观遗传调控，这对CRC患者构成了严重威胁。蛋白质的翻译后修饰（PTM）涉及向特定残基添加化学基团、糖类或蛋白质，从而微调蛋白质的稳定性、定位或相互作用，以协调复杂的生物学过程。最近越来越多的研究表明，PTM的失调，如磷酸化、泛素化和糖基化，在CRC转移级联反应中起关键作用。在这里，我们总结了翻译后修饰在CRC转移各个方面的作用及其详细分子机制的最新进展。此外，还讨论了靶向PTM的药物进展及其与其他抗癌药物的协同作用，这可能为CRC治疗提供新的靶点并提高治疗效果。
