Caparros-Gonzalez Rafael A, Romero-Gonzalez Borja, Gonzalez-Perez Raquel, Lucena-Prieto Lidia, Perez-Garcia Miguel, Cruz-Quintana Francisco, Peralta-Ramirez Maria Isabel
Department of Nursing, Faculty of Health Sciences, University of Granada, 18071 Granada, Spain.
Mind, Brain, and Behavior Research Center (CIMCYC), University of Granada, 18011 Granada, Spain.
J Clin Med. 2019 Nov 19;8(11):2015. doi: 10.3390/jcm8112015.
Maternal stress during pregnancy can affect fetal development during certain sensitive periods.
To longitudinally assess maternal hair cortisol levels during pregnancy, and the postpartum along with neonatal hair cortisol levels that could be associated with infant neurodevelopment at six months of age.
A sample of 41 pregnant women longitudinally assessed during the first, second, and third trimester and the postpartum, along with their 41 full-term neonates participated in this study. Hair cortisol levels were assessed from participants. Infant neurodevelopment was assessed by means of the Bayley Scale of Infants Development, Third Edition at age six months.
Maternal hair cortisol levels in the first and second trimester accounted for 24% and 23%, respectively, of variance of infant gross motor development ( < 0.05). Maternal hair cortisol levels during the postpartum accounted for 31% of variance of infant cognitive development ( < 0.05), and 25% of variance of infant gross motor development ( < 0.05). Neonatal hair cortisol levels accounted for 28% of variance of infant gross motor development ( < 0.05).
The preconception and prenatal time are sensitive periods related to infant neurodevelopment along with the cortisol levels surrounding the fetus while in the womb. Pregnant women could be assessed for hair cortisol levels while attending a prenatal appointment.
孕期母亲压力在某些敏感期会影响胎儿发育。
纵向评估孕期及产后母亲头发中的皮质醇水平，以及与6个月大婴儿神经发育相关的新生儿头发皮质醇水平。
41名孕妇及其41名足月儿参与了本研究，对孕妇在孕早期、孕中期、孕晚期及产后进行纵向评估，并检测其头发中的皮质醇水平。婴儿神经发育通过贝利婴幼儿发展量表第三版在6个月大时进行评估。
孕早期和孕中期母亲头发中的皮质醇水平分别解释了婴儿粗大运动发育差异的24%和23%（P<0.05）。产后母亲头发中的皮质醇水平解释了婴儿认知发育差异的31%（P<0.05），以及婴儿粗大运动发育差异的25%（P<0.05）。新生儿头发中的皮质醇水平解释了婴儿粗大运动发育差异的28%（P<0.05）。
受孕前和孕期是与婴儿神经发育相关的敏感期，同时胎儿在子宫内时周围的皮质醇水平也与之相关。孕妇在产前检查时可进行头发皮质醇水平检测。
