Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.
Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Transl Psychiatry. 2022 Jun 6;12(1):232. doi: 10.1038/s41398-022-01985-z.
During the Coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is universally susceptible to all types of populations. In addition to the elderly and children becoming the groups of great concern, pregnant women carrying new lives need to be even more alert to SARS-CoV-2 infection. Studies have shown that pregnant women infected with SARS-CoV-2 can lead to brain damage and post-birth psychiatric disorders in offspring. It has been widely recognized that SARS-CoV-2 can affect the development of the fetal nervous system directly or indirectly. Pregnant women are recommended to mitigate the effects of COVID-19 on the fetus through vaccination, nutritional supplements, and psychological support. This review summarizes the possible mechanisms of the nervous system effects of SARS-CoV-2 infection on their offspring during the pregnancy and analyzes the available prophylactic and treatment strategies to improve the prognosis of fetal-related neuropsychiatric diseases after birth.
在 2019 冠状病毒病（COVID-19）大流行期间，严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）普遍易感染所有人群。除了老年人和儿童成为特别关注的群体外，携带新生命的孕妇更需要警惕 SARS-CoV-2 感染。研究表明，孕妇感染 SARS-CoV-2 可导致后代大脑损伤和产后精神障碍。人们普遍认识到，SARS-CoV-2 可以直接或间接影响胎儿神经系统的发育。建议孕妇通过接种疫苗、营养补充和心理支持来减轻 COVID-19 对胎儿的影响。本综述总结了 SARS-CoV-2 感染对孕妇后代神经系统的可能作用机制，并分析了现有的预防和治疗策略，以改善出生后与胎儿相关的神经精神疾病的预后。
