HBV 感染在 HIV 驱动的免疫抑制中。
HBV Infection in HIV-Driven Immune Suppression.
机构信息
Clinical Infectious Diseases, Department of System Medicine, Tor Vergata University, 00133 Rome, Italy.
出版信息
Viruses. 2019 Nov 19;11(11):1077. doi: 10.3390/v11111077.
Abstract
Worldwide, approximately 10% of all human immunodeficiency virus (HIV)-infected people are also chronically coinfected with hepatitis B virus (HBV). HBV infection has a poor prognosis in HIV-positive people and has been documented by an increased risk of developing chronic HBV infection (CHB), progression to liver fibrosis and end-stage liver disease (ESLD) and evolution of hepatocellular carcinoma (HCC). Furthermore, in HIV patients, HBV-resolved infection is often associated with the appearance of HBV-DNA, which configures occult HBV infection (OBI) as a condition to be explored in coinfected patients. In this narrative review we summarize the main aspects of HBV infection in HIV-positive patients, emphasizing the importance of carefully considering the coinfected patient in the context of therapeutic strategies of antiretroviral therapy.
摘要
在全球范围内，约有 10%的人类免疫缺陷病毒 (HIV) 感染者也同时慢性感染乙型肝炎病毒 (HBV)。HBV 感染在 HIV 阳性者中预后不良，并已通过增加发生慢性 HBV 感染 (CHB)、进展为肝纤维化和终末期肝病 (ESLD) 以及发展为肝细胞癌 (HCC) 的风险得到证实。此外，在 HIV 患者中，HBV 已解决的感染常伴有 HBV-DNA 的出现，这将隐匿性 HBV 感染 (OBI) 定义为需要在合并感染患者中探索的一种情况。在本叙述性综述中，我们总结了 HIV 阳性患者中 HBV 感染的主要方面，强调了在抗逆转录病毒治疗的治疗策略背景下，仔细考虑合并感染患者的重要性。
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