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HBcAb seropositivity is correlated with poor HIV viremia control in an Italian cohort of HIV/HBV-coinfected patients on first-line therapy.HBcAb 血清学阳性与意大利一线治疗的 HIV/HBV 合并感染患者的 HIV 病毒血症控制不佳相关。
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Occult hepatitis B and HIV infection.隐匿性乙型肝炎和 HIV 感染。
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Prevalence and Clinical Outcomes of Poor Immune Response Despite Virologically Suppressive Antiretroviral Therapy Among Children and Adolescents With Human Immunodeficiency Virus in Europe and Thailand: Cohort Study.尽管在欧洲和泰国的艾滋病毒患儿和青少年中采用了病毒学抑制性抗逆转录病毒治疗，但免疫反应不佳的流行情况和临床结局：队列研究。
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Human immunodeficiency virus and hepatotropic viruses co-morbidities as the inducers of liver injury progression.人类免疫缺陷病毒和嗜肝病毒合并感染作为肝损伤进展的诱导因素。
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HBV 感染在 HIV 驱动的免疫抑制中。

HBV Infection in HIV-Driven Immune Suppression.

机构信息

Clinical Infectious Diseases, Department of System Medicine, Tor Vergata University, 00133 Rome, Italy.

出版信息

Viruses. 2019 Nov 19;11(11):1077. doi: 10.3390/v11111077.

DOI:10.3390/v11111077
PMID:31752284
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6893694/
Abstract

Worldwide, approximately 10% of all human immunodeficiency virus (HIV)-infected people are also chronically coinfected with hepatitis B virus (HBV). HBV infection has a poor prognosis in HIV-positive people and has been documented by an increased risk of developing chronic HBV infection (CHB), progression to liver fibrosis and end-stage liver disease (ESLD) and evolution of hepatocellular carcinoma (HCC). Furthermore, in HIV patients, HBV-resolved infection is often associated with the appearance of HBV-DNA, which configures occult HBV infection (OBI) as a condition to be explored in coinfected patients. In this narrative review we summarize the main aspects of HBV infection in HIV-positive patients, emphasizing the importance of carefully considering the coinfected patient in the context of therapeutic strategies of antiretroviral therapy.

摘要

在全球范围内，约有 10%的人类免疫缺陷病毒 (HIV) 感染者也同时慢性感染乙型肝炎病毒 (HBV)。HBV 感染在 HIV 阳性者中预后不良，并已通过增加发生慢性 HBV 感染 (CHB)、进展为肝纤维化和终末期肝病 (ESLD) 以及发展为肝细胞癌 (HCC) 的风险得到证实。此外，在 HIV 患者中，HBV 已解决的感染常伴有 HBV-DNA 的出现，这将隐匿性 HBV 感染 (OBI) 定义为需要在合并感染患者中探索的一种情况。在本叙述性综述中，我们总结了 HIV 阳性患者中 HBV 感染的主要方面，强调了在抗逆转录病毒治疗的治疗策略背景下，仔细考虑合并感染患者的重要性。