Son Wonsoo, Park Jaechan, Kang Dong-Hun, Han Young-Min, Choi Yeon-Ju, Ohk Boram
Department of Neurosurgery, School of Medicine, Kyungpook National University, Daegu, Korea.
Department of Clinical Trial Center, Kyungpook National University Hospital, Daegu, Korea.
J Korean Neurosurg Soc. 2020 May;63(3):380-385. doi: 10.3340/jkns.2018.0224. Epub 2019 Nov 22.
A consensus regarding the ideal regimen for urokinase (UK) thrombolysis subsequent to stereotactic spontaneous intracerebral hemorrhage aspiration has yet to be established. The purpose of this study is to evaluate the efficacy of UK thrombolysis relative to when the regimen is changed.
Venous blood from 30 heathy volunteers was obtained for this in-vitro study. Various concentrations of UK solution were added to microcentrifuge tubes containing the clotted blood. The efficacy of UK thrombolysis was identified by checking the weight of lysed hematoma following various time intervals with different concentrations of UK solution. Group one, the "3×4" group involved four administrations every 3 hours over 12 hours, and group two, the "6×2" group involved two administrations every 6 hours over 12 hours.
More hematoma was lysed in the 3×4 group than the 6×2 group across all concentration levels (however, the differences were only significant between groups at the 500 and 1000 IU concentration levels, p<0.05). There were no significant differences of lysed hematoma among the various UK solution concentrations within groups.
This study suggests that frequent administrations of UK thrombolysis may result in a greater degree of lysed hematoma in comparison to a higher concentration of UK.
立体定向自发性脑出血抽吸术后尿激酶（UK）溶栓的理想方案尚未达成共识。本研究的目的是评估UK溶栓方案改变时的溶栓效果。
本体外研究采集了30名健康志愿者的静脉血。将不同浓度的UK溶液加入含有凝血的微量离心管中。通过在不同浓度的UK溶液作用不同时间间隔后检查溶解血肿的重量来确定UK溶栓的效果。第一组，“3×4”组在12小时内每3小时给药4次，第二组，“6×2”组在12小时内每6小时给药2次。
在所有浓度水平下，“3×4”组溶解的血肿均比“6×2”组多（然而，仅在500和1000 IU浓度水平时两组间差异有统计学意义，p<0.05）。组内不同UK溶液浓度间溶解血肿量无显著差异。
本研究表明，与高浓度UK相比，频繁进行UK溶栓可能导致更大程度的血肿溶解。
