Peñas M, Sánchez-Prieto J, Martín-González E, Fernández M, López-Pérez M J
Departamento de Bioquímica, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
Rev Esp Fisiol. 1988 Mar;44(1):51-6.
Brain mitochondria purified by phase partition showed a higher rate of 14C-leucine incorporation into proteins with an endogenous source of ATP than with an exogenous ATP-generating system. Under the former conditions the presence of atractyloside increased the 14C-leucine incorporation into proteins. The effects of different valinomycin concentrations plus attractyloside on intramitochondrial ATP levels and 14C-leucine incorporation into proteins have been studied. The results indicate that the protein synthesis in brain mitochondria is dependent on the intramitochondrial ATP concentration.
