Section of Plant Biology, School of Integrative Plant Science, Cornell University, Ithaca, NY, USA.
Boyce Thompson Institute, Ithaca, NY, USA.
Plant Signal Behav. 2020;15(1):1694224. doi: 10.1080/15592324.2019.1694224. Epub 2019 Nov 22.
The periphery in animal nuclei is generally considered to be a transcriptionally repressive environment. Recent studies indicate that chromatin-based mechanisms establish a similar situation in plant nuclei. We demonstrated recently that the loss of CRWN nuclear lamina proteins in Arabidopsis leads to the misregulation of a group of genes involved in plant defense. How this defense response is triggered is largely unknown. Here, we briefly review recent findings that identify several layers of chromatin-based regulation responsible for this response. Further, we introduce new data suggesting that histone H3 lysine 27 tri-methylation levels are reduced in the absence of CRWNs near genes encoding transcription factors regulating SA biosynthesis, providing an explanation for SA induction. These discoveries begin to uncover the interplay between nuclear architecture and stress response in plants.
动物细胞核的外围通常被认为是转录抑制环境。最近的研究表明，基于染色质的机制在植物细胞核中建立了类似的情况。我们最近证明，拟南芥中 CRWN 核层蛋白的缺失会导致一组参与植物防御的基因失调。这种防御反应是如何触发的，在很大程度上还不清楚。在这里，我们简要回顾了最近的发现，这些发现确定了几个负责这种反应的基于染色质的调节层。此外，我们引入了新的数据，表明在缺乏 CRWN 的情况下，参与调控 SA 生物合成的转录因子的基因附近，组蛋白 H3 赖氨酸 27 三甲基化水平降低，这为 SA 的诱导提供了一个解释。这些发现开始揭示植物中核结构与应激反应之间的相互作用。
