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尼泊尔东部莫朗地区结核病患者的糖尿病及其相关危险因素研究。

Study of the magnitude of diabetes and its associated risk factors among the tuberculosis patients of Morang, Eastern Nepal.

机构信息

School of Public Health and Community Medicine (SPHCM), B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal.

出版信息

BMC Public Health. 2019 Nov 21;19(1):1545. doi: 10.1186/s12889-019-7891-x.

Abstract

BACKGROUND

WHO addresses the infectious disease like Tuberculosis, and non- communicable disease like Diabetes among the top 10 causes of death worldwide, which collectively leads to increasing mortality and premature death especially in developing countries. Hence, the present study aims to assess the prevalence of diabetes and its associated risk factors among the tuberculosis patient of Morang, Eastern Nepal.

METHODS

A cross-sectional study was carried out among the 320 respondents undergoing tuberculosis treatment of Morang district. Respondents from eight randomly selected DOTS centers were selected purposively. The Fasting Blood Sugar and 2-h Post-Prandial Blood Sugar were assessed in the laboratory of respective DOTS center by the glucose oxidase method. An interview for socio-demographic and other variables was conducted using a pretested semi-structured questionnaire based on WHO-STEP Instrument for chronic disease and excerpt from DASS-21 was used for the variable stress.

RESULTS

The prevalence of diabetes, pre-diabetic and glucose intolerance among tuberculosis patient was 11.9, 17.2, and 17.8% respectively. Additionally, the univariate analysis reported, user of tobacco products, current alcohol consumers, family history of diabetes and stress level, to have positive association with diabetes, while the multivariate analysis reported, the current alcohol consumer as the significant predictor of diabetes among the tuberculosis patient.

CONCLUSION

A significant portion of the respondents were diabetic, impaired glucose tolerance and pre-diabetic, which supports the fact of diabetes being comorbid with tuberculosis. Hence, it shifts the focus on the bidirectional screening of tuberculosis and diabetes.

摘要

背景

世界卫生组织(WHO)将结核病等传染病和糖尿病等非传染性疾病列为全球十大死因,这些疾病共同导致死亡率和早逝率上升,尤其是在发展中国家。因此,本研究旨在评估尼泊尔东部莫朗地区结核病患者中糖尿病的患病率及其相关危险因素。

方法

对莫朗地区 320 名接受结核病治疗的患者进行了横断面研究。从八个随机选定的直接督导下短程化疗(DOTS)中心选择了受访者。在各自 DOTS 中心的实验室,使用葡萄糖氧化酶法评估空腹血糖和餐后 2 小时血糖。使用基于世卫组织慢性病 STEP 工具的预测试半结构式问卷对社会人口统计学和其他变量进行访谈,并使用 DASS-21 的摘录对压力变量进行评估。

结果

糖尿病、糖尿病前期和糖耐量受损在结核病患者中的患病率分别为 11.9%、17.2%和 17.8%。此外,单因素分析报告称,使用烟草制品、当前饮酒者、糖尿病家族史和压力水平与糖尿病呈正相关,而多因素分析报告称,当前饮酒者是结核病患者中糖尿病的显著预测因素。

结论

相当一部分受访者患有糖尿病、葡萄糖耐量受损和糖尿病前期,这支持了糖尿病与结核病共病的事实。因此,它将重点转移到结核病和糖尿病的双向筛查上。

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