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采用 PET 成像技术对犬脑内 [F] altanserin 弹丸注射的动力学分析。

Kinetic analysis of [F] altanserin bolus injection in the canine brain using PET imaging.

机构信息

Laboratory of Radiopharmacy, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium.

Small animal Departments, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.

出版信息

BMC Vet Res. 2019 Nov 21;15(1):415. doi: 10.1186/s12917-019-2165-5.

DOI:10.1186/s12917-019-2165-5
PMID:31752848
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6873736/
Abstract

BACKGROUND

Currently, [F] altanserin is the most frequently used PET-radioligand for serotonin (5-HT) receptor imaging in the human brain but has never been validated in dogs. In vivo imaging of this receptor in the canine brain could improve diagnosis and therapy of several behavioural disorders in dogs. Furthermore, since dogs are considered as a valuable animal model for human psychiatric disorders, the ability to image this receptor in dogs could help to increase our understanding of the pathophysiology of these diseases. Therefore, five healthy laboratory beagles underwent a 90-min dynamic PET scan with arterial blood sampling after [F] altanserin bolus injection. Compartmental modelling using metabolite corrected arterial input functions was compared with reference tissue modelling with the cerebellum as reference region.

RESULTS

The distribution of [F] altanserin in the canine brain corresponded well to the distribution of 5-HT receptors in human and rodent studies. The kinetics could be best described by a 2-Tissue compartment (2-TC) model. All reference tissue models were highly correlated with the 2-TC model, indicating compartmental modelling can be replaced by reference tissue models to avoid arterial blood sampling.

CONCLUSIONS

This study demonstrates that [F] altanserin PET is a reliable tool to visualize and quantify the 5-HT receptor in the canine brain.

摘要

背景

目前，[F] altanserin 是最常用于人类大脑中血清素（5-HT）受体成像的 PET 放射性配体，但从未在犬中得到验证。在犬脑中对该受体进行体内成像可以改善犬几种行为障碍的诊断和治疗。此外，由于犬被认为是人类精神疾病的有价值的动物模型，因此能够对犬进行这种受体成像可以帮助我们增加对这些疾病病理生理学的理解。因此，五只健康的实验室比格犬在 [F] altanserin 推注后进行了 90 分钟的动态 PET 扫描和动脉采血。使用校正代谢物的动脉输入函数的房室模型与以小脑为参比区的参比组织模型进行比较。

结果

[F] altanserin 在犬脑中的分布与人类和啮齿动物研究中 5-HT 受体的分布非常吻合。动力学可以通过 2 组织室（2-TC）模型来最佳描述。所有参比组织模型与 2-TC 模型高度相关，表明房室模型可以用参比组织模型来替代，以避免动脉采血。

结论

本研究表明，[F] altanserin PET 是一种可靠的工具，可用于可视化和定量犬脑中的 5-HT 受体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd77/6873736/c8ad3919c2ae/12917_2019_2165_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd77/6873736/ee3cd0dd37e3/12917_2019_2165_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd77/6873736/c444a85a44bb/12917_2019_2165_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd77/6873736/e3dfd7228e79/12917_2019_2165_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd77/6873736/d76875592250/12917_2019_2165_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd77/6873736/c8ad3919c2ae/12917_2019_2165_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd77/6873736/ee3cd0dd37e3/12917_2019_2165_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd77/6873736/c444a85a44bb/12917_2019_2165_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd77/6873736/e3dfd7228e79/12917_2019_2165_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd77/6873736/d76875592250/12917_2019_2165_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd77/6873736/c8ad3919c2ae/12917_2019_2165_Fig5_HTML.jpg

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