抗淋巴细胞球蛋白对人淋巴细胞的细胞毒性作用。

Cytotoxic effect of anti-lymphocytic globulin on human lymphoid cells.

作者信息

Heyworth M F, Truelove S C

出版信息

Ric Clin Lab. 1979 Oct-Dec;9(4):345-50. doi: 10.1007/BF02904570.

Abstract

The cytotoxic activity of two anti-lymphocytic globulin (ALG) preparations was investigated by measurement of 51Cr release from human peripheral blood mononuclear cells and tonsil lymphocytes incubated with ALG in the presence of complement. Both types of ALG had a greater complement-dependent cytotoxic effect on tonsil lymphocytes than on peripheral blood mononuclear cells. The ALG preparations were more cytotoxic for a population of tonsil lymphocytes enriched in non-T cells than for one enriched in T cells. This finding does not support the view that ALG has a selective action on T lymphocytes.

摘要

通过测量在补体存在的情况下与抗淋巴细胞球蛋白（ALG）一起孵育的人外周血单个核细胞和扁桃体淋巴细胞释放的51Cr，研究了两种抗淋巴细胞球蛋白（ALG）制剂的细胞毒性活性。两种类型的ALG对扁桃体淋巴细胞的补体依赖性细胞毒性作用均比对外周血单个核细胞的作用更强。ALG制剂对富含非T细胞的扁桃体淋巴细胞群体的细胞毒性比对富含T细胞的群体更强。这一发现不支持ALG对T淋巴细胞具有选择性作用的观点。