Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, 1720 2nd Ave South, Birmingham AL 35294-0012, USA.
Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, 1720 2nd Ave South, Birmingham AL 35294-0012, USA.
Clin Liver Dis. 2020 Feb;24(1):89-106. doi: 10.1016/j.cld.2019.09.006. Epub 2019 Oct 31.
Drug-induced liver injury (DILI) is an uncommon but significant cause of liver injury and need for liver transplant. DILI in the setting of chronic liver disease (CLD) is poorly understood. Clinical features of patients presenting with DILI in the setting of CLD are similar to those without CLD with the exception of a higher incidence of diabetes among those with CLD and DILI. Diagnosis of DILI in CLD is difficult because there are no objective biomarkers and current causality assessments have not been studied in this population. Differentiating DILI from exacerbation of underlying liver disease is even more challenging.
药物性肝损伤（DILI）是导致肝损伤和需要进行肝移植的一个不常见但很重要的原因。在慢性肝病（CLD）背景下的 DILI 尚不清楚。在 CLD 背景下出现 DILI 的患者的临床表现与没有 CLD 的患者相似，除了 CLD 和 DILI 患者中糖尿病的发病率更高。在 CLD 中诊断 DILI 很困难，因为没有客观的生物标志物，而且目前的因果关系评估尚未在该人群中进行研究。区分 DILI 与潜在肝病的恶化更具挑战性。
