Emerg Infect Dis. 2023 Dec;29(12):2482-2487. doi: 10.3201/eid2912.230250.
Avian paramyxovirus type 1 (APMV-1) is a virus of birds that results in a range of outcomes, from asymptomatic infections to outbreaks of systemic respiratory and neurologic disease, depending on the virus strain and the avian species affected. Humans are rarely affected; those who are predominantly experience mild conjunctivitis. We report a fatal case of neurologic disease in a 2-year-old immunocompromised child in Australia. Metagenomic sequencing and histopathology identified the causative agent as the pigeon variant of APMV-1. This diagnosis should be considered in neurologic conditions of undefined etiologies. Agnostic metagenomic sequencing methods are useful in such settings to direct diagnostic and therapeutic efforts.
禽流感病毒 1 型（APMV-1）是一种鸟类病毒，根据病毒株和受感染的鸟类物种的不同，其结果范围从无症状感染到全身呼吸道和神经系统疾病爆发不等。人类很少受到影响；受影响的人主要表现为轻度结膜炎。我们报告了澳大利亚一名 2 岁免疫功能低下儿童发生致命性神经系统疾病的病例。宏基因组测序和组织病理学将病原体确定为鸽变异的 APMV-1。在病因不明的神经系统疾病中应考虑这一诊断。在这种情况下，无偏宏基因组测序方法有助于指导诊断和治疗。
