Nandi A, Wadhwani N, Randhir K, Wagh G, Joshi S R
Mother and Child Health, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed to be University), Pune Satara Road, Pune, Maharashtra 411043, India.
Department of Obstetrics and Gynaecology, Bharati Medical College and Hospital, Bharati Vidyapeeth (Deemed to be University), Pune Satara Road, Pune, Maharashtra 411043, India.
Prostaglandins Leukot Essent Fatty Acids. 2020 Jun;157:102030. doi: 10.1016/j.plefa.2019.102030. Epub 2019 Nov 6.
Preeclampsia is a pregnancy complication, associated with an increased risk of maternal and neonatal morbidity and mortality. The etiology of preeclampsia is not yet fully understood, although the current literature indicates an up regulation of inflammatory mediators. Vitamin D is known to have anti-inflammatory properties and influence vascular function. Fatty acids are also known to regulate inflammation in pregnancy. This study was carried out to explore the association of maternal vitamin D and fatty acids in pregnancy. The present study includes 69 normotensive control (NC) and 50 women with preeclampsia (PE). Maternal and cord serum 25-hydroxyvitamin D [25(OH)D] levels were lower (p<0.01for both) in women with PE compared to NC women. Maternal plasma total polyunsaturated fatty acids (PUFA) levels were lower (p<0.05) while levels of total saturated fatty acids (SFA) and total monounsaturated fatty acids (MUFA) were higher (p<0.05 for both) in women with PE. Cord erythrocyte PUFA levels were higher (p<0.01) in PE women. Maternal 25(OH)D levels were negatively associated with maternal systolic and diastolic BP (p<0.01 for both). Maternal 25(OH)D levels were positively associated with maternal total PUFA (p<0.01) and negatively associated with maternal total SFA (p<0.05), total MUFA (p<0.01). This study for the first time demonstrates an association of maternal vitamin D with fatty acid levels in pregnancy. Our results suggest that vitamin D and fatty acids may work in concert to regulate fetal growth.
子痫前期是一种妊娠并发症，与孕产妇和新生儿发病及死亡风险增加相关。尽管目前的文献表明炎症介质上调，但子痫前期的病因尚未完全明确。已知维生素D具有抗炎特性并影响血管功能。脂肪酸也已知可调节孕期炎症。本研究旨在探讨孕期母体维生素D与脂肪酸之间的关联。本研究纳入了69名血压正常的对照者（NC）和50名单纯性子痫前期（PE）患者。与NC组女性相比，PE组女性的母体和脐带血清25-羟基维生素D [25(OH)D]水平较低（两者均p<0.01）。PE组女性的母体血浆总多不饱和脂肪酸（PUFA）水平较低（p<0.05），而总饱和脂肪酸（SFA）和总单不饱和脂肪酸（MUFA）水平较高（两者均p<0.05）。PE组女性的脐带红细胞PUFA水平较高（p<0.01）。母体25(OH)D水平与母体收缩压和舒张压呈负相关（两者均p<0.01）。母体25(OH)D水平与母体总PUFA呈正相关（p<0.01），与母体总SFA呈负相关（p<0.05），与总MUFA呈负相关（p<0.01）。本研究首次证明了孕期母体维生素D与脂肪酸水平之间的关联。我们的结果表明，维生素D和脂肪酸可能协同作用以调节胎儿生长。
