Pastor-Cantizano Noelia, Ko Dae Kwan, Angelos Evan, Pu Yunting, Brandizzi Federica
MSU-DOE Plant Research Lab and Plant Biology Department, Michigan State University, East Lansing, MI 48824, USA.
MSU-DOE Plant Research Lab and Plant Biology Department, Michigan State University, East Lansing, MI 48824, USA; Department of Plant Biology, Michigan State University, East Lansing, MI 48824, USA.
Trends Biochem Sci. 2020 Feb;45(2):123-136. doi: 10.1016/j.tibs.2019.10.008. Epub 2019 Nov 18.
The endoplasmic reticulum (ER) is responsible for the synthesis of one-third of the cellular proteome and is constantly challenged by physiological and environmental situations that can perturb its homeostasis and lead to the accumulation of misfolded secretory proteins, a condition referred to as ER stress. In response, the ER evokes a set of intracellular signaling processes, collectively known as the unfolded protein response (UPR), which are designed to restore biosynthetic capacity of the ER. As single-cell organisms evolved into multicellular life, the UPR complexity has increased to suit their growth and development. In this review, we discuss recent advances in the understanding of the UPR, emphasizing conserved UPR elements between plants and metazoans and highlighting unique plant-specific features.
内质网（ER）负责合成细胞蛋白质组的三分之一，并且不断受到生理和环境状况的挑战，这些状况会扰乱其稳态并导致错误折叠的分泌蛋白积累，这种情况称为内质网应激。作为响应，内质网引发了一系列细胞内信号传导过程，统称为未折叠蛋白反应（UPR），其旨在恢复内质网的生物合成能力。随着单细胞生物进化为多细胞生物，未折叠蛋白反应的复杂性增加以适应其生长和发育。在本综述中，我们讨论了在理解未折叠蛋白反应方面的最新进展，强调了植物和后生动物之间保守的未折叠蛋白反应元件，并突出了植物特有的独特特征。
