Tanabe T, Kobayashi T, Yoshida S, Mizuguchi Y
Department of Central Clinical Laboratory, University Hospital, University of Occupational and Environmental Health, Kitakyushu, Japan.
J UOEH. 1988 Sep 1;10(3):297-303. doi: 10.7888/juoeh.10.297.
Susceptibilities of Gram-negative bacterial strains isolated at the University Hospital in 1987 to six beta-Lactam antibiotics (azthreonam cefmetazole, ceftizoxime, latamoxef, aminobenzyl-penicillin and piperacillin) and two aminoglycoside antibiotics (gentamicin and amikacin) were examined by agar dilution and the agar diffusion method. Results obtained from both methods correlated well in most of the strains. Most of the strains belonging to Escherichia coli, Klebsiella oxytoca, Klebsiella pneumoniae and Proteus mirabilis were sensitive to the beta-lactam antibiotics except aminobenzyl-penicillin and piperacillin. They were also sensitive to aminoglycoside antibiotics. Most strains of Citrobacter freundii, Enterobacter cloacae and Serratia marcescens were sensitive to azthreonam, latamoxef and aminoglycosides, but were less sensitive to other beta-lactams. Acinetobacter calcoaceticus was generally resistant to beta-lactams except ceftizoxime, but was sensitive to aminoglycosides. More than half of the strains of Pseudomonas aeruginosa were sensitive to azthreonam, piperacillin and aminoglycoside antibiotics and only latamoxef was active in Pseudomonas maltophilia.
1987年从大学医院分离出的革兰氏阴性菌菌株对六种β-内酰胺抗生素（氨曲南、头孢美唑、头孢唑肟、拉氧头孢、氨苄青霉素和哌拉西林）以及两种氨基糖苷类抗生素（庆大霉素和阿米卡星）的敏感性，通过琼脂稀释法和琼脂扩散法进行了检测。两种方法获得的结果在大多数菌株中相关性良好。大多数属于大肠杆菌、产酸克雷伯菌、肺炎克雷伯菌和奇异变形杆菌的菌株对β-内酰胺抗生素敏感，但对氨苄青霉素和哌拉西林除外。它们对氨基糖苷类抗生素也敏感。弗氏柠檬酸杆菌、阴沟肠杆菌和粘质沙雷氏菌的大多数菌株对氨曲南、拉氧头孢和氨基糖苷类敏感，但对其他β-内酰胺类敏感性较低。醋酸钙不动杆菌除对头孢唑肟外通常对β-内酰胺类耐药，但对氨基糖苷类敏感。超过一半的铜绿假单胞菌菌株对氨曲南、哌拉西林和氨基糖苷类抗生素敏感，而在嗜麦芽窄食单胞菌中只有拉氧头孢有活性。
