Department of Ultrasound, Pudong New Area People's Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Pudong, Shanghai, China (mainland).
Department of General Surgery, Pudong New Area People's Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Pudong, Shanghai, China (mainland).
Med Sci Monit. 2019 Nov 22;25:8836-8842. doi: 10.12659/MSM.917344.
BACKGROUND The present study aimed to assess the correlation between prostate volume and prostate cancer (PCa) detection by strain elastography (SE)-guided targeted biopsy (TB) compared with conventional transrectal ultrasound (TRUS)-guided systematic biopsy (SB). MATERIAL AND METHODS This retrospective study enrolled 357 patients suspected to have PCa. All patients received TRUS-guided 10-core SB and SE-guided TB. The sensitivity for PCa detected by SE-guided TB was compared with that by TRUS-guided SB, in combination with prostate biopsy pathology. The correlation between the prostate volume and the detection rate of SE-guided TB was investigated. RESULTS PCa was pathologically confirmed in 151 out of 357 patients. The by-patient detection rate of TRUS-guided SB was 72.8% (110/151). Subsequently, a further increase of 6.6% (10/151) in PCa determination was obtained by the SE-guided TB. The sensitivity of SE-guided TB for patients with prostate volume <30 ml, 30-50 ml, 51-80 ml, and >80 ml was 91.7% (44/48), 80.3% (53/66), 70.4% (19/27), and 40.0% (4/10), respectively (p=0.002). For patients with a prostate volume less than 30 ml, SE-guided TB (91.7%) had a higher sensitivity than SB (62.5%) (p<0.007). CONCLUSIONS SE-guided TB has a higher detection rate of PCa in comparison with TRUS-guided SB. There was also a negative correlation between prostate volume and SE-guided TB. Therefore, use of SE-guided TB may complement use of conventional SB, especially for patients with smaller prostate volume.
本研究旨在评估与传统经直肠超声（TRUS）引导的系统活检（SB）相比，应变弹性成像（SE）引导的靶向活检（TB）与前列腺体积和前列腺癌（PCa）检测之间的相关性。
本回顾性研究纳入了 357 例疑似患有 PCa 的患者。所有患者均接受了 TRUS 引导的 10 针 SB 和 SE 引导的 TB。比较 SE 引导的 TB 检测 PCa 的敏感性与 TRUS 引导的 SB 结合前列腺活检病理结果。研究了前列腺体积与 SE 引导的 TB 检测率之间的相关性。
357 例患者中，151 例经病理证实患有 PCa。TRUS 引导的 SB 的患者检出率为 72.8%（110/151）。随后，通过 SE 引导的 TB 进一步增加了 6.6%（10/151）的 PCa 检出率。对于前列腺体积<30ml、30-50ml、51-80ml 和>80ml 的患者，SE 引导的 TB 的敏感性分别为 91.7%（44/48）、80.3%（53/66）、70.4%（19/27）和 40.0%（4/10）（p=0.002）。对于前列腺体积<30ml 的患者，SE 引导的 TB（91.7%）的敏感性高于 SB（62.5%）（p<0.007）。
与 TRUS 引导的 SB 相比，SE 引导的 TB 具有更高的 PCa 检出率。前列腺体积与 SE 引导的 TB 之间也存在负相关。因此，SE 引导的 TB 可补充传统 SB 的应用，特别是对于前列腺体积较小的患者。
