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Association of time to antibiotics and clinical outcomes in patients with fever and neutropenia during chemotherapy for cancer: a systematic review.癌症化疗期间发热伴中性粒细胞减少症患者使用抗生素的时间与临床结局的关系：系统评价。
Support Care Cancer. 2020 Mar;28(3):1369-1383. doi: 10.1007/s00520-019-04961-4. Epub 2019 Jul 1.
2
What do families want to improve in the management of paediatric febrile neutropenia during anti-cancer treatment? Report of a patient/public involvement group.在抗癌治疗期间，家庭希望在小儿发热性中性粒细胞减少症的管理方面改善哪些方面？一个患者/公众参与小组的报告。
BMJ Paediatr Open. 2019 Mar 1;3(1):e000398. doi: 10.1136/bmjpo-2018-000398. eCollection 2019.
3
Neutropenic diets to prevent cancer infections: updated systematic review and meta-analysis.中性粒细胞减少症饮食预防癌症感染：更新的系统评价和荟萃分析。
BMJ Support Palliat Care. 2019 Dec;9(4):425-433. doi: 10.1136/bmjspcare-2018-001742. Epub 2019 Apr 4.
4
Outpatient treatment for people with cancer who develop a low-risk febrile neutropaenic event.对发生低风险发热性中性粒细胞减少事件的癌症患者进行门诊治疗。
Cochrane Database Syst Rev. 2019 Mar 19;3(3):CD009031. doi: 10.1002/14651858.CD009031.pub2.
5
Early discontinuation of antibiotics for febrile neutropenia versus continuation until neutropenia resolution in people with cancer.癌症患者发热性中性粒细胞减少症中抗生素早期停用与持续使用至中性粒细胞减少症缓解的比较。
Cochrane Database Syst Rev. 2019 Jan 3;1(1):CD012184. doi: 10.1002/14651858.CD012184.pub2.
6
Effect of Levofloxacin Prophylaxis on Bacteremia in Children With Acute Leukemia or Undergoing Hematopoietic Stem Cell Transplantation: A Randomized Clinical Trial.左氧氟沙星预防急性白血病或造血干细胞移植患儿菌血症的随机临床试验。
JAMA. 2018 Sep 11;320(10):995-1004. doi: 10.1001/jama.2018.12512.
7
Efficacy of pre-emptive versus empirical antifungal therapy in children with cancer and high-risk febrile neutropenia: a randomized clinical trial.预先性与经验性抗真菌治疗在癌症合并高危发热性中性粒细胞减少症儿童中的疗效：一项随机临床试验。
J Antimicrob Chemother. 2018 Oct 1;73(10):2860-2866. doi: 10.1093/jac/dky244.
8
Systematic review and meta-analysis investigating the efficacy and safety of probiotics in people with cancer.系统评价和荟萃分析研究益生菌在癌症患者中的疗效和安全性。
Support Care Cancer. 2018 Aug;26(8):2503-2509. doi: 10.1007/s00520-018-4216-z. Epub 2018 Apr 27.
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Gut Microbiome Composition Predicts Infection Risk During Chemotherapy in Children With Acute Lymphoblastic Leukemia.肠道微生物组组成可预测急性淋巴细胞白血病患儿化疗期间的感染风险。
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Antibiotic-resistant Gram-negative Blood Stream Infections in Children With Cancer: A Review of Epidemiology, Risk Factors, and Outcome.癌症患儿的耐抗生素革兰氏阴性菌血流感染：流行病学、危险因素及结局综述
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癌症治疗中儿童感染预防与管理的最新进展。

Recent advances in the prevention and management of infections in children undergoing treatment for cancer.

作者信息

Phillips Bob

机构信息

Centre for Reviews and Dissemination, University of York, York, Yorkshire, YO10 5DD, UK.

Leeds Children's Hospital, Leeds General Infirmary, Leeds, Yorkshire, LS1 9EX, UK.

出版信息

F1000Res. 2019 Nov 12;8. doi: 10.12688/f1000research.19337.1. eCollection 2019.

DOI:10.12688/f1000research.19337.1
PMID:31754423
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6852340/
Abstract

A major consequence of the intensive multi-modal chemotherapy commonly used to treat malignancies in childhood is life-threatening infection, frequently during periods of profound neutropenia. Recent advances have been made in all areas of management, from trying to prevent infection to getting patients off antimicrobials and home again in the shortest, safest way. Potential avenues of further research are outlined for readers to be aware of in the next few years.

摘要

常用于治疗儿童恶性肿瘤的强化多模式化疗的一个主要后果是危及生命的感染，这种感染经常发生在严重中性粒细胞减少的时期。从试图预防感染到以最短、最安全的方式让患者停用抗菌药物并再次回家，管理的各个方面都取得了最新进展。本文概述了未来几年可供读者了解的进一步研究的潜在途径。