Faculty of Dental Medicine of University of Porto, Rua Dr. Manuel Pereira da Silva, 4200-393, Porto, Portugal.
Int Orthop. 2020 Feb;44(2):231-236. doi: 10.1007/s00264-019-04433-8. Epub 2019 Nov 21.
To re-assess the scientific literature to ascertain if there is scientific evidence to support antibiotic prophylaxis in patients with periodontal disease as a means to decrease the risk of prosthetic joint infections.
Prosthetic joint infections occur in approximately 0.3-2% of patients and, of these, around 6-13% are thought to be caused by oral bacteria. Antibiotic prophylaxis prior to dental procedures as a means to prevent a prosthetic joint infection has been controversial throughout the years. However, it remains unclear to what extent it has a beneficial effect. We do know that bacteraemia of oral origin is directly proportional to any ongoing inflammation or infection, and that a diseased periodontium may act as an entry for bacteria to spread to distant locations, through the bloodstream, and potentially be the cause of distant site infections.
Updated literature search using the PubMed (Medline), and the Clarivate Analytics databases, to identify eligible articles since the previous searches up to April 2019 (last 5 years).
No studies that relate periodontal disease to the development of a prosthetic joint infection were found.
Currently, there is no evidence to support or exclude the need of antibiotic prophylaxis as a means to decrease the risk of prosthetic joint infections in patients with periodontal disease.
重新评估科学文献，以确定是否有科学证据支持牙周病患者使用抗生素预防作为降低人工关节感染风险的方法。
人工关节感染在大约 0.3-2%的患者中发生，其中约 6-13%被认为是由口腔细菌引起的。在进行牙科手术前使用抗生素预防作为预防人工关节感染的方法一直存在争议。然而，目前仍不清楚它在多大程度上具有有益的效果。我们确实知道，口腔来源的菌血症与任何持续的炎症或感染成正比，而患病的牙周组织可能作为细菌通过血液传播到远处并可能导致远处部位感染的入口。
使用 PubMed（Medline）和 Clarivate Analytics 数据库更新文献搜索，以确定自前两次搜索以来（过去 5 年）符合条件的文章。
没有发现将牙周病与人工关节感染发展相关的研究。
目前，没有证据支持或排除在牙周病患者中使用抗生素预防作为降低人工关节感染风险的方法的必要性。
