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局部使用氟尿嘧啶致严重坏死性炎症皮肤反应。

Severe necrotising inflammatory skin reaction to topical 5-fluorouracil.

机构信息

Gokhale Eye Hospital, Anant Building, Gokhale Road South, Dadar West, Mumbai, Maharashtra, India.

出版信息

Indian J Ophthalmol. 2019 Dec;67(12):2066-2068. doi: 10.4103/ijo.IJO_373_19.

DOI:10.4103/ijo.IJO_373_19
PMID:31755461
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6896520/
Abstract

I report two patients who developed a severe necrotising inflammatory skin reaction with ulceration and hemorrhagic crusting during the first cycle of chemotherapy with 1% 5-Fluorouracil eye drops for Ocular surface squamous neoplasia. The skin reaction subsided on stoppage of the drops and the use of a steroid ointment. 5 fluorouracil therapy was terminated and the patients were shifted to interferon therapy subsequently.

摘要

我报告了两例患者，他们在接受 1% 5-氟尿嘧啶滴眼液治疗眼表面鳞状肿瘤的第一个化疗周期中，出现严重的坏死性炎症性皮肤反应，伴有溃疡和出血性结痂。停止使用滴眼剂和使用类固醇软膏后，皮肤反应消退。随后停止了 5-氟尿嘧啶治疗，并将患者转为干扰素治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/566e/6896520/6e414c1dae9a/IJO-67-2066-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/566e/6896520/be59e675b69b/IJO-67-2066-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/566e/6896520/539ec679b75b/IJO-67-2066-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/566e/6896520/6e414c1dae9a/IJO-67-2066-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/566e/6896520/be59e675b69b/IJO-67-2066-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/566e/6896520/539ec679b75b/IJO-67-2066-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/566e/6896520/6e414c1dae9a/IJO-67-2066-g003.jpg

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1
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本文引用的文献

1
Comparison of Topical 5-Fluorouracil and Interferon Alfa-2b as Primary Treatment Modalities for Ocular Surface Squamous Neoplasia.眼表面鳞状上皮肿瘤的局部 5-氟尿嘧啶和干扰素 Alfa-2b 作为主要治疗方式的比较。
Am J Ophthalmol. 2019 Mar;199:216-222. doi: 10.1016/j.ajo.2018.11.007. Epub 2018 Nov 22.
2
Topical application of 5-fluorouracil 5 percent cream associated with severe neutropenia: discussion of a case and review of systemic reactions after topical treatment with 5-fluorouracil.外用5%氟尿嘧啶乳膏伴严重中性粒细胞减少症：一例病例讨论及外用氟尿嘧啶治疗后全身反应的综述
Dermatol Online J. 2018 Apr 15;24(4):13030/qt974797j7.
3
Exuberant inflammatory reaction to occlusion of topical 5-fluorouracil (FU) under a continuous positive airway pressure (CPAP) mask: A warning to dermatologists and patients.
持续气道正压通气（CPAP）面罩下外用5-氟尿嘧啶（FU）闭塞引起的过度炎症反应：给皮肤科医生和患者的警示
JAAD Case Rep. 2016 Jul 14;2(3):278-80. doi: 10.1016/j.jdcr.2016.05.011. eCollection 2016 May.
4
Topical 5-Fluorouracil 1% as Primary Treatment for Ocular Surface Squamous Neoplasia.1%的局部用氟尿嘧啶作为眼表鳞状上皮肿瘤的主要治疗方法
Ophthalmology. 2016 Jul;123(7):1442-8. doi: 10.1016/j.ophtha.2016.02.034. Epub 2016 Mar 27.
5
Topical medical therapies for ocular surface tumors.眼表肿瘤的局部药物治疗
Semin Ophthalmol. 2006 Jul-Sep;21(3):161-9. doi: 10.1080/08820530500351694.
6
Life-threatening toxicity in a dihydropyrimidine dehydrogenase-deficient patient after treatment with topical 5-fluorouracil.一名二氢嘧啶脱氢酶缺乏患者在局部应用5-氟尿嘧啶治疗后出现危及生命的毒性反应。
Clin Cancer Res. 1999 Aug;5(8):2006-11.
7
Topical application of 5-fluorouracil in premalignant lesions of cornea, conjunctiva and eyelid.
Doc Ophthalmol. 1986 Dec 30;64(1):31-42. doi: 10.1007/BF00166683.