Qi Hui-Zhou, Wang Wu-Zhou, He Jun-Yan, Ma Yun, Xiao Fang-Zhu, He Shu-Ya
Institute of Biochemistry and Molecular Biology, Hengyang Medical College, University of South China, Hengyang, 421001, China; Function Laboratory Center, Hengyang Medical College, University of South China, Hengyang, 421001, China; Hengyang Key Laboratory for Biological Effects of Nuclear Radiation, University of South China, Hengyang, 421001, China.
Institute of Biochemistry and Molecular Biology, Hengyang Medical College, University of South China, Hengyang, 421001, China; Hengyang Key Laboratory for Biological Effects of Nuclear Radiation, University of South China, Hengyang, 421001, China.
Res Microbiol. 2020 Mar;171(2):45-54. doi: 10.1016/j.resmic.2019.11.002. Epub 2019 Nov 19.
Deinococcus radiodurans is famous for its extreme resistance to various stresses such as ionizing radiation (IR), desiccation and oxidative stress. The underlying mechanism of exceptional resistance of this robust bacterium still remained unclear. However, the antioxidative system of D. radiodurans has been considered to be the determinant factor for its unparalleled resistance and protects the proteome during stress, then the DNA repair system and metabolic system exert their functions to restore the cell to normal physiological state. The antioxidative system not only equipped with the common reactive oxygen species (ROS) scavenging enzymes (e.g., catalase and superoxide dismutase) but also armed with a variety of non-enzyme antioxidants (e.g., carotenoids and manganese species). And the small manganese complexes play an important role in the antioxidative system of D. radiodurans. Recent studies have characterized several regulators (e.g., PprI and PprM) in D. radiodurans, which play critical roles in the protection of the bacteria from various stresses. In this review, we offer a panorama of the progress regarding the characteristics of the antioxidative system in D. radiodurans and its application in the future.
耐辐射球菌以其对多种应激（如电离辐射、干燥和氧化应激）的极端抗性而闻名。这种顽强细菌卓越抗性的潜在机制仍不清楚。然而，耐辐射球菌的抗氧化系统被认为是其无与伦比抗性的决定因素，在应激期间保护蛋白质组，然后DNA修复系统和代谢系统发挥功能使细胞恢复到正常生理状态。抗氧化系统不仅配备了常见的活性氧（ROS）清除酶（如过氧化氢酶和超氧化物歧化酶），还拥有多种非酶抗氧化剂（如类胡萝卜素和锰化合物）。并且小锰复合物在耐辐射球菌的抗氧化系统中发挥重要作用。最近的研究已经鉴定了耐辐射球菌中的几种调节因子（如PprI和PprM），它们在保护细菌免受各种应激方面起着关键作用。在这篇综述中，我们全面介绍了耐辐射球菌抗氧化系统的特性及其未来应用方面的进展。
