College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China.
College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China; Guangxi Key Laboratory of Biorefinery, Nanning 530003, China.
Int J Biol Macromol. 2020 Aug 1;156:1045-1052. doi: 10.1016/j.ijbiomac.2019.11.146. Epub 2019 Nov 19.
A novel sustained-release matrix tablet was developed through wet granulation by using oxidized konjac glucomannan-cassava starch (OKGM-CS) and sucrose esters (SE) as excipients. OKGM-CS treated by dry heat exhibited low solubility and swelling power, indicating that it might be a potential adjuvant for sustained-release drug formulations. SE incorporation significantly decreased the porosity and swelling rates of tablets and retarded drug release. Tablets containing SE with an HLB value of 5 displayed better sustained-release performance, the cumulative release decreased from 94.36% to 83.29% and MDT increased from 4.50 h to 5.79 h. All these findings suggest the potential of OKGM-CS and SE as novel sustained-release agents for matrix tablets.
采用湿法制粒工艺，以氧化魔芋葡甘聚糖-木薯淀粉（OKGM-CS）和蔗糖酯（SE）为辅料，研制了一种新型的缓释骨架片。经干热处理的 OKGM-CS 表现出低溶解度和溶胀能力，这表明它可能是一种潜在的用于缓控释药物制剂的辅料。SE 的加入显著降低了片剂的孔隙率和溶胀率，并延缓了药物的释放。含有 HLB 值为 5 的 SE 的片剂表现出更好的缓释性能，累积释放率从 94.36%降低到 83.29%，MDT 从 4.50 小时增加到 5.79 小时。所有这些发现表明 OKGM-CS 和 SE 具有作为基质片剂新型缓控释剂的潜力。
