Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Department of Herbal Medicine, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
ScientificWorldJournal. 2021 Jan 15;2021:6672277. doi: 10.1155/2021/6672277. eCollection 2021.
Natural polymers have become attractive to pharmaceutical researchers and manufacturers as excipients because of the advantages they possess relative to their semisynthetic and synthetic counterparts. Although pectin from some natural sources has been investigated for use in the pharmaceutical industry as excipients, pectin from okra, which is readily available and used as food in many parts of the world, has not been extensively investigated as a potential control-releasing agent in tablets. This study thus seeks to determine the drug release modifying properties of okra pectin from 6 different genotypes of okra cultivated and available in Ghana. Pectin was extracted from different genotypes of okra, physicochemical properties were characterized, and control release matrix tablets of metformin (F1-F6) were formulated using the wet granulation method with the okra pectin as the drug release modifier, respectively. The drug content, drug release, and mathematical kinetic modeling of drug release from the matrix tablets were studied. Drug release profiles of formulated matrix tablets were compared to an existing (innovator) brand of metformin sustained-release tablet on the market using the similarity and difference factors, respectively. The extracted pectin had percentage yields ranging from 6 to 20% w/w with swelling indexes and water-holding capacities between 300-500% and 9-10 mL/g, respectively, and pH within 6.20-6.90. All the formulated batches passed the drug content test (90-105%) and produced the optimal release of metformin (>80%) after 24 hours. Different batches of formulated tablets exhibited different mechanisms of drug release with batches F1, F2, F5, and F6 being similar (ƒ values being >50 and ƒ values <15) to the innovator brand. Pectin from the 6 different genotypes of okra studied has the potential for use as drug release modifiers in pharmaceutical manufacturing of control release matrix tablets and production of more affordable medicines.
天然聚合物因其相对于半合成和合成聚合物具有的优势，已成为制药研究人员和制造商在作为赋形剂时的首选。虽然某些来源的果胶已被用于制药工业作为赋形剂，但在世界许多地区，作为食物使用的秋葵果胶尚未被广泛研究作为片剂的潜在控释剂。因此，本研究旨在确定来自加纳种植和可用的 6 种不同秋葵基因型的秋葵果胶的药物释放调节特性。从不同基因型的秋葵中提取果胶，对其理化性质进行表征，并分别采用湿法制粒法，以秋葵果胶作为药物释放调节剂，制备二甲双胍（F1-F6）控释基质片。研究了药物释放的药物含量、药物释放和数学动力学模型。通过相似因子和差异因子，将所制备的基质片的药物释放曲线与市场上现有的（创新型）二甲双胍缓释片进行比较。提取的果胶的产率范围为 6-20%w/w，溶胀指数和持水能力分别为 300-500%和 9-10mL/g，pH 值在 6.20-6.90 之间。所有制剂批次均通过药物含量测试（90-105%），并在 24 小时后产生二甲双胍的最佳释放（>80%）。不同批次的制剂片显示出不同的药物释放机制，F1、F2、F5 和 F6 批次与创新型品牌相似（ƒ值>50 和 ƒ值<15）。研究的 6 种不同秋葵基因型的果胶具有作为药物释放调节剂在制药工业中用于控制释放基质片的潜力，以及生产更经济实惠的药物的潜力。
