Aanisah Nuur, Wardhana Yoga W, Chaerunisaa Anis Y, Budiman Arif
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Tadulako University, Palu 94118, Indonesia.
Polymers (Basel). 2022 Jun 23;14(13):2550. doi: 10.3390/polym14132550.
Glucomannan (GM)-a polysaccharide generally extracted from the tuber of -has great potential as a filler-binder in direct compression, disintegrant in tablets, or gelling agent due to its strong hydrophilicity and extremely high viscosity. However, it has poor water resistance and low mechanical strength when used as an excipient in solid form. Several physical and chemical modifications have been carried out to improve these drawbacks. Chemical modification affects the characteristics of GM based on the DS. Carboxymethylation improves GM functionality by modifying its solubility and viscosity, which in turn allows it to bind water more efficiently and thus improve its elongation and gel homogeneity. Meanwhile, physical modification enhances functionality through combination with other excipients to improve mechanical properties and modify swelling ability and drug release from the matrix. This review discusses extraction of GM and its modification to enhance its applicability as an excipient in solid form. Modified GM is a novel excipient applicable in the pharmaceutical industry for direct compression, as a tablet disintegrant, a film-forming agent, and for encapsulation of macromolecular compounds or drug carriers for controlled release.
葡甘露聚糖（GM）——一种通常从魔芋块茎中提取的多糖——由于其强亲水性和极高的粘度，在直接压片中作为填充粘合剂、片剂崩解剂或胶凝剂具有巨大潜力。然而，当它以固体形式用作辅料时，其耐水性差且机械强度低。已经进行了几种物理和化学改性来改善这些缺点。化学改性基于取代度（DS）影响葡甘露聚糖的特性。羧甲基化通过改变其溶解度和粘度来改善葡甘露聚糖的功能，这反过来又使其能够更有效地结合水分，从而提高其伸长率和凝胶均匀性。同时，物理改性通过与其他辅料结合来增强功能，以改善机械性能并改变溶胀能力以及药物从基质中的释放。本文综述了葡甘露聚糖的提取及其改性，以提高其作为固体辅料的适用性。改性葡甘露聚糖是一种新型辅料，可应用于制药行业的直接压片、作为片剂崩解剂、成膜剂以及用于包封大分子化合物或药物载体以实现控释。
