图形索引复杂度作为高频振荡的新型替代标志物，用于划定癫痫发作起始区。

Graph index complexity as a novel surrogate marker of high frequency oscillations in delineating the seizure onset zone.

机构信息

Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada; Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, AB, Canada.

Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada; Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, AB, Canada.

出版信息

Clin Neurophysiol. 2020 Jan;131(1):78-87. doi: 10.1016/j.clinph.2019.09.019. Epub 2019 Nov 4.

DOI:10.1016/j.clinph.2019.09.019

PMID:31756595

Abstract

OBJECTIVE

To investigate the Graph Index Complexity (uGIC) as a marker of high frequency oscillatory (HFO) activity, the seizure onset zone (SOZ), and surgical outcome.

METHODS

The SOZ, rates of HFOs at two thresholds (broad, strict), and uGIC were determined using EEG data from 41 patients. The correlation between HFOs and uGIC were calculated. HFOs and uGIC were compared within and outside the SOZ. Postsurgical outcome was compared to the colocalization of HFOs and resected SOZ.

RESULTS

There was significant correlation between uGIC and both broad (r = 0.69, p < 0.0005) and strict HFOs (r = 0.48, p < 0.0005). All were significantly greater within the SOZ overall, but only in 17/41 (strict, uGIC) or 18/41 (broad) patients. HFO markers were significantly greater within the SOZ for 8/15 patients with positive postsurgical outcomes, but not for any patients with negative outcomes (0/5).

CONCLUSION

The uGIC is a marker of HFO activity, while HFOs and uGIC are markers of the SOZ overall. Colocalization of HFOs and the SOZ has strong positive predictive value for postsurgical outcome, but poor negative predictive value.

SIGNIFICANCE

The uGIC is an objective surrogate marker of HFO activity independent of identifying discrete HFO events.

摘要

目的

探讨图形指数复杂度（uGIC）作为高频振荡（HFO）活动、起始区（SOZ）和手术结果的标志物。

方法

使用 41 名患者的脑电图数据确定 SOZ、两个阈值（广泛、严格）的 HFO 率和 uGIC。计算 HFO 与 uGIC 之间的相关性。比较 SOZ 内和 SOZ 外的 HFO 和 uGIC。将术后结果与 HFO 和切除的 SOZ 的重合进行比较。

结果

uGIC 与广泛（r=0.69，p<0.0005）和严格 HFO（r=0.48，p<0.0005）均呈显著相关。总体而言，SOZ 内的 uGIC 均显著更高，但仅在 17/41 例（严格、uGIC）或 18/41 例（广泛）患者中如此。在 8/15 例术后结果阳性的患者中，HFO 标志物在 SOZ 内显著更高，但在任何术后结果阴性的患者中均无显著更高（0/5）。