From Mayo Systems Electrophysiology Laboratory, Department of Neurology (H.G., M.S., B.M.B., V.K., D.K.-J., J.B., G.A.W., B.H.B.), and Department of Physiology & Biomedical Engineering (B.M.B., V.K., G.A.W., B.H.B.), Mayo Clinic, Rochester, MN; International Clinical Research Center (J.C.), St. Anne's University Hospital, Brno, Czech Republic; The Krembil Neuroscience Centre (D.M.G.), Toronto, Canada; and Czech Institute of Informatics, Robotics, and Cybernetics (V.K.), Czech Technical University in Prague, Czech Republic.
Neurology. 2018 Feb 20;90(8):e639-e646. doi: 10.1212/WNL.0000000000004998. Epub 2018 Jan 24.
To assess the variation in baseline and seizure onset zone interictal high-frequency oscillation (HFO) rates and amplitudes across different anatomic brain regions in a large cohort of patients.
Seventy patients who had wide-bandwidth (5 kHz) intracranial EEG (iEEG) recordings during surgical evaluation for drug-resistant epilepsy between 2005 and 2014 who had high-resolution MRI and CT imaging were identified. Discrete HFOs were identified in 2-hour segments of high-quality interictal iEEG data with an automated detector. Electrode locations were determined by coregistering the patient's preoperative MRI with an X-ray CT scan acquired immediately after electrode implantation and correcting electrode locations for postimplant brain shift. The anatomic locations of electrodes were determined using the Desikan-Killiany brain atlas via FreeSurfer. HFO rates and mean amplitudes were measured in seizure onset zone (SOZ) and non-SOZ electrodes, as determined by the clinical iEEG seizure recordings. To promote reproducible research, imaging and iEEG data are made freely available (msel.mayo.edu).
Baseline (non-SOZ) HFO rates and amplitudes vary significantly in different brain structures, and between homologous structures in left and right hemispheres. While HFO rates and amplitudes were significantly higher in SOZ than non-SOZ electrodes when analyzed regardless of contact location, SOZ and non-SOZ HFO rates and amplitudes were not separable in some lobes and structures (e.g., frontal and temporal neocortex).
The anatomic variation in SOZ and non-SOZ HFO rates and amplitudes suggests the need to assess interictal HFO activity relative to anatomically accurate normative standards when using HFOs for presurgical planning.
评估在一个大的患者队列中，不同解剖脑区的基线和发作起始区（SOZ）间高频振荡（HFO）率和振幅的变化。
在 2005 年至 2014 年间，通过识别 70 名在手术评估耐药性癫痫期间接受宽频带（5 kHz）颅内脑电图（iEEG）记录的患者，这些患者有高分辨率 MRI 和 CT 成像。通过自动探测器在高质量的发作间期 iEEG 数据的 2 小时段中识别离散 HFO。通过将患者术前 MRI 与电极植入后立即获得的 X 射线 CT 扫描进行配准，确定电极的位置，并校正电极位置以补偿植入后大脑移位。使用 Desikan-Killiany 脑图谱通过 FreeSurfer 确定电极的解剖位置。使用临床 iEEG 发作记录确定 SOZ 和非 SOZ 电极的 HFO 率和平均振幅。为了促进可重复性研究，成像和 iEEG 数据免费提供（msel.mayo.edu）。
基线（非 SOZ）HFO 率和振幅在不同的脑结构中存在显著差异，并且在左右半球的同源结构之间也存在差异。虽然在不考虑接触位置的情况下，SOZ 电极的 HFO 率和振幅明显高于非 SOZ 电极，但在某些叶和结构中（例如，额颞新皮质），SOZ 和非 SOZ 的 HFO 率和振幅不可分离。
SOZ 和非 SOZ 的 HFO 率和振幅的解剖变异表明，在使用 HFO 进行术前规划时，需要相对于解剖准确的正常标准评估发作间期 HFO 活动。
