Department of Internal Medicine, Owani Hospital, Aomori, Japan; Department of Gastroenterology, Hirosaki University Graduate School of Medicine, Aomori, Japan.
Department of Gastroenterology, Hirosaki University Graduate School of Medicine, Aomori, Japan.
Cytokine. 2020 Feb;126:154927. doi: 10.1016/j.cyto.2019.154927. Epub 2019 Nov 27.
Cardiovascular disease (CVD) is a leading cause of mortality in nonalcoholic fatty liver disease (NAFLD). The aim of this study was to investigate the relationship of leptin-to-adiponectin (L/A) ratio with hepatic steatosis and arterial stiffness in NAFLD.
The subjects were 871 Japanese adults who participated in a health survey. Dietary intake, body composition, lipid profile, serum interleukin-6 (IL-6), leptin, and adiponectin were analyzed. NAFLD was defined as fatty liver on ultrasonography in the absence of other causes of steatosis. Arterial stiffness was evaluated by the brachial-ankle pulse wave velocity (baPWV).
The subjects with NAFLD had a greater body mass index (BMI) and body fat percentage (BFP); a higher intake of daily energy (kcal) and carbohydrates; and a higher prevalence of hypertension, diabetes, and hyperlipidemia. The subjects with NAFLD had higher serum leptin and lower serum adiponectin concentrations and a higher L/A ratio than subjects without NAFLD. The L/A ratio increased with increasing severity of steatosis. The L/A ratio showed positive correlations with BMI and BFP, and a negative correlation with age. Women had higher L/A ratio and BFP levels than men regardless of the presence or absence of NAFLD. There was a weak positive correlation between baPWV and severity of steatosis. BaPWV was strongly correlated with age, while no relation was found between baPWV and L/A ratio. IL-6 level was correlated with baPVW and age, while the correlation between Il and 6 level and L/A ratio was very weak. The L/A ratio was correlated with triglycerides and the ratio of total cholesterol to high-density lipoprotein-cholesterol.
L/A ratio and arterial stiffness were associated with the severity of steatosis, whereas there was no correlation between L/A ratio and arterial stiffness in NAFLD. These findings suggest that not only leptin and adiponectin but also other factors might be involved in the pathogenesis for atherosclerosis in NAFLD.
心血管疾病（CVD）是非酒精性脂肪性肝病（NAFLD）患者死亡的主要原因。本研究旨在探讨瘦素与脂联素（L/A）比值与 NAFLD 患者肝脂肪变性和动脉僵硬的关系。
本研究纳入了 871 名参加健康调查的日本成年人。分析了饮食摄入、身体成分、血脂谱、血清白细胞介素-6（IL-6）、瘦素和脂联素。NAFLD 定义为超声检查无其他脂肪变性原因的脂肪肝。通过肱踝脉搏波速度（baPWV）评估动脉僵硬。
NAFLD 患者的体重指数（BMI）和体脂百分比（BFP）较高；每日能量（千卡）和碳水化合物摄入量较高；高血压、糖尿病和高脂血症的患病率较高。与无 NAFLD 患者相比，NAFLD 患者的血清瘦素水平较高，而血清脂联素水平较低，L/A 比值较高。L/A 比值随着肝脂肪变性严重程度的增加而增加。L/A 比值与 BMI 和 BFP 呈正相关，与年龄呈负相关。无论是否存在 NAFLD，女性的 L/A 比值和 BFP 水平均高于男性。baPWV 与肝脂肪变性严重程度呈弱正相关。baPWV 与年龄密切相关，而与 L/A 比值无关。IL-6 水平与 baPVW 和年龄相关，而 IL-6 水平与 L/A 比值的相关性很弱。L/A 比值与三酰甘油和总胆固醇与高密度脂蛋白胆固醇的比值相关。
L/A 比值和动脉僵硬与肝脂肪变性的严重程度相关，而在 NAFLD 中，L/A 比值与动脉僵硬之间无相关性。这些发现表明，在 NAFLD 中，不仅瘦素和脂联素，而且其他因素可能参与动脉粥样硬化的发病机制。
