Magalhães G C B, Feitoza F M, Moreira S B, Carmo A V, Souto F J D, Reis S R L, Martins M S F, Gomes da Silva M H G
Mestrado em Biociências, Faculdade de Nutrição, FANUT/UFMT, Cuiabá, Brasil.
J Hum Nutr Diet. 2014 Apr;27 Suppl 2:301-12. doi: 10.1111/jhn.12110. Epub 2013 Jun 22.
The present study aimed to investigate the relationship between adiponectinaemia and food intake among obese women with nonalcoholic fatty liver disease (NAFLD).
In total, 60 obese women were examined by abdominal ultrasound for liver steatosis and subcutaneous and visceral adiposity. A standard interview (including questions about alcohol intake, medical history and physical activity), a physical examination (including height, weight, body mass index, waist and hip circumferences, waist-to-hip ratio, and body composition) and biochemical and clinical parameters (including serum glucose and insulin, homeostatic model assessment insulin resistance, lipid profile, aminotransferases, C-reactive protein, adiponectin, leptin, resistin, tumour necrosis factor-α, interleukin-6 levels and blood pressure) were performed. Food intake was evaluated by a qualitative food frequency questionnaire.
Twenty-four NAFLD patients and thirty-six controls were analysed. The Mann-Whitney test showed lower adiponectin levels in the liver disease group compared to controls (P < 0.05). The Pearson correlation coefficient indicated that adiponectinaemia was negatively correlated with lipid profile and serum tumour necrosis factor-α (P = 0.05) and was positively associated with adiposity measures and serum leptin (P < 0.05). By simple linear regression, all of these variables predicted serum adiponectin levels. Chi-squared and Fisher's exact tests indicated that, in both groups, food intake showed no differences, although sucrose and fatty foods were associated with lower adiponectin levels in the liver disease group (P < 0.05 and P < 0.05, respectively), as well as in the control group (P = 0.05 and P < 0.05, respectively).
Hypoadiponectinaemia in NAFLD was associated with dietary sucrose and fatty food intake, emphasising the important role of diet in the occurrence of this disease.
本研究旨在调查非酒精性脂肪性肝病（NAFLD）肥胖女性的脂联素血症与食物摄入量之间的关系。
总共60名肥胖女性接受了腹部超声检查，以评估肝脏脂肪变性以及皮下和内脏脂肪情况。进行了标准访谈（包括有关酒精摄入量、病史和身体活动的问题）、体格检查（包括身高、体重、体重指数、腰围和臀围、腰臀比以及身体成分）以及生化和临床参数检测（包括血清葡萄糖和胰岛素、稳态模型评估胰岛素抵抗、血脂谱、转氨酶、C反应蛋白、脂联素、瘦素、抵抗素、肿瘤坏死因子-α、白细胞介素-6水平和血压）。通过定性食物频率问卷评估食物摄入量。
分析了24名NAFLD患者和36名对照。曼-惠特尼检验显示，与对照组相比，肝病组的脂联素水平较低（P<0.05）。皮尔逊相关系数表明，脂联素血症与血脂谱和血清肿瘤坏死因子-α呈负相关（P=0.05），与肥胖指标和血清瘦素呈正相关（P<0.05）。通过简单线性回归分析，所有这些变量均能预测血清脂联素水平。卡方检验和费舍尔精确检验表明，在两组中，食物摄入量均无差异，尽管在肝病组中，蔗糖和高脂肪食物与较低的脂联素水平相关（分别为P<0.05和P<0.05），在对照组中也是如此（分别为P=0.05和P<0.05）。
NAFLD患者的低脂联素血症与饮食中蔗糖和高脂肪食物的摄入有关，这凸显了饮食在该疾病发生中的重要作用。
