Arnet Isabelle, Rothen Jean-Pierre, Hersberger Kurt E
Department of Pharmaceutical Sciences, Pharmaceutical Care Research Group, University of Basel, Basel CH-4056, Switzerland.
Pharmacy (Basel). 2019 Nov 20;7(4):155. doi: 10.3390/pharmacy7040155.
Several methods exist for measuring medication adherence. The Time4Med device (Adherence Innovations, Hong Kong) is a small, electronic card to affix on medication packaging that records date and time of intakes when a button is pushed. We aimed to validate the device with an emphasis on polypharmacy. Twenty volunteers used Time4Med devices with a virtual thrice daily intake over 14 days. Diary-recorded date and time were compared to electronically-stored events. Functionality, reliability and recovery for different stress conditions were calculated. User's acceptability was assessed with the System Usability Scale (SUS). Eleven elderly outpatients (mean age 80.2 ± 8.1 years) taking >3 medications daily used the device over 4 weeks. Volunteers logged 847 events. Functionality (100%), sensitivity (94.9%), specificity (99.4%) and recovery (100%) were high. Dropping the smart card and storing it in a refrigerator caused either the recording of false events or no recording at all. The mean SUS score was 82.6 (SD 14.8), demonstrating excellent acceptability. Satisfaction was very high for volunteers and patients, except for pushing the button. Time4Med devices are highly accurate in recording, retaining and delivering electronic data of multiple medication intake. They are well accepted by elderly patients. They can be recommended in clinical studies and for practitioners who desire to elucidate adherence patterns of ambulatory patients.
测量药物依从性有多种方法。Time4Med设备（香港依从性创新公司）是一种小型电子卡，可粘贴在药品包装上，按下按钮时可记录服药日期和时间。我们旨在以多药治疗为重点对该设备进行验证。20名志愿者在14天内使用Time4Med设备进行虚拟的每日三次服药记录。将日记记录的日期和时间与电子存储的事件进行比较。计算了不同压力条件下的功能、可靠性和恢复情况。使用系统可用性量表（SUS）评估用户的可接受性。11名每天服用超过3种药物的老年门诊患者（平均年龄80.2±8.1岁）使用该设备超过4周。志愿者记录了847次事件。功能（100%）、敏感性（94.9%）、特异性（99.4%）和恢复率（100%）都很高。掉落智能卡或将其存放在冰箱中会导致记录错误事件或根本没有记录。SUS平均得分为82.6（标准差14.8），表明可接受性极佳。除了按下按钮外，志愿者和患者的满意度都非常高。Time4Med设备在记录、保存和传输多种药物摄入的电子数据方面高度准确。它们很受老年患者的欢迎。可在临床研究中推荐使用，也适用于希望阐明门诊患者依从模式的从业者。
