巴西麻风病（麻风）流行地区 HIV 感染者和未感染者的 PGL-1 和 LID-1 抗体水平。
PGL-1 and LID-1 antibody levels in HIV-infected and HIV-uninfected individuals in a Hansen's disease (leprosy) endemic area of Brazil.
机构信息
Department of Social Medicine, Federal University of Espírito Santo, Vitória, ES, Brazil; Programme of Postgraduation of Infectious Diseases, Infectious Diseases Unit, Federal University of Espírito Santo, Vitória, ES, Brazil.
Laboratory of Cellular Microbiology, Oswaldo Cruz Institute, Rio de Janeiro, RJ, Brazil.
出版信息
Immunobiology. 2020 Jan;225(1):151866. doi: 10.1016/j.imbio.2019.11.001. Epub 2019 Nov 10.
Serological tests for subclinical Mycobacterium leprae infection based on antibodies to phenolic glycolipid-1 (PGL-1) and leprosy IDRI diagnostic-1 (LID-1) have not been compared in HIV-infected and uninfected individuals. PGL-1 seropositivity by ELISA was 6.0 % (21/350) in HIV-infected compared with 29.1 % (102/350) in HIV-uninfected individuals (p < 0.001); LID-1 seropositivity was 45.4 % (159/350) in HIV-infected compared with 50.3 % (153/304) in HIV-uninfected individuals (p = 0.21). In HIV-infected individuals, LID-1 but not PGL-1 antibody levels were inversely associated with CD4+ cell count (p = 0.02). These differential associations of HIV infection and CD4 count with PGL-1 and LID-1 have implications for M leprae immunodiagnostic tools and require replication.
尚未比较过针对分支杆菌酚糖脂-1（PGL-1）和麻风病 IDRI 诊断-1（LID-1）抗体的基于血清学的潜伏性麻风分枝杆菌感染检测方法在 HIV 感染者和未感染者中的差异。ELISA 法检测 PGL-1 血清阳性率在 HIV 感染者中为 6.0%（21/350），而在 HIV 未感染者中为 29.1%（102/350）（p<0.001）；在 HIV 感染者中，LID-1 血清阳性率为 45.4%（159/350），而在 HIV 未感染者中为 50.3%（153/304）（p=0.21）。在 HIV 感染者中，LID-1 抗体水平而非 PGL-1 抗体水平与 CD4+细胞计数呈负相关（p=0.02）。HIV 感染和 CD4 计数与 PGL-1 和 LID-1 的这种差异关联对麻风分枝杆菌免疫诊断工具具有重要意义，需要进一步研究证实。
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