Universidad Autónoma de Nayarit, Laboratorio de Contaminación y Toxicología, Secretaría de Investigación y Posgrado, Nayarit, Mexico; Posgrado en Ciencias Biológico Agropecuarias, Universidad Autónoma de Nayarit, Tepic, Nayarit, Mexico.
Universidad Autónoma de Nayarit, Laboratorio de Contaminación y Toxicología, Secretaría de Investigación y Posgrado, Nayarit, Mexico.
Nutr Metab Cardiovasc Dis. 2020 Jan 3;30(1):40-48. doi: 10.1016/j.numecd.2019.08.013. Epub 2019 Sep 10.
Paraoxonase 1 (PON1) is considered to play a crucial role as an anti-atherosclerotic factor. The PON1 activity is affected by genetic polymorphisms, environmental factors, age, sex, lifestyle, pharmaceutical drugs, and dietary factors. The aim of this study was to evaluate the association between macro- and micronutrients as well as PON1 concentration and activities in patients with cardiovascular diseases (CVD), cardiovascular risk factors but no CVD (CRF), and in healthy controls (control group).
A case-control study was carried out with 356 volunteers from the Mexican Institute of Social Security, Mexico. Clinical parameters, lipid profile, PON1 activities (AREase, LACase, CMPAase and PONase), and PON1 concentration were evaluated. There was a differential intake of macro- and micronutrients among the study groups. The intake of proteins and carbohydrates was higher in the CVD group than in the CFR and control groups (p < 0.05). AREase, LACase, and CMPAase activities and PON1 concentration were lowest in the CVD group.
LACase and CMPAase activities, as well as PON1 concentration, could be included in the battery of CVD predictive biomarkers in the Mexican population.
对氧磷酶 1（PON1）被认为是一种重要的抗动脉粥样硬化因子。PON1 活性受遗传多态性、环境因素、年龄、性别、生活方式、药物和饮食因素的影响。本研究旨在评估宏量和微量营养素以及 PON1 浓度和活性与心血管疾病（CVD）患者、有心血管危险因素但无 CVD（CRF）患者和健康对照组（对照组）之间的相关性。
对来自墨西哥社会保障研究所的 356 名志愿者进行了病例对照研究。评估了临床参数、血脂谱、PON1 活性（AREase、LACase、CMPAase 和 PONase）和 PON1 浓度。研究组之间存在宏量和微量营养素的摄入差异。CVD 组的蛋白质和碳水化合物摄入量高于 CFR 组和对照组（p<0.05）。CVD 组的 AREase、LACase 和 CMPAase 活性以及 PON1 浓度最低。
LACase 和 CMPAase 活性以及 PON1 浓度可作为墨西哥人群 CVD 预测生物标志物的组合之一。
