Department of Health Sciences, University "Magna Græcia" of Catanzaro, Catanzaro, Italy.
Department of Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.
Cardiovasc Pathol. 2020 Jan-Feb;44:107163. doi: 10.1016/j.carpath.2019.107163. Epub 2019 Oct 25.
In cardiac myxomas, the malignant transformation process, selecting incidental gene mutations and leading to loss of proliferation control, has not a so drastic effects in terms of growth rate of tumor mass, but frequently the particular location of lesion engrosses the high risk for health. For accurate cancer cell profiling, it is important to establish the embryologic origin of malignant cells and their initial commitments, above all, in the sight of therapeutic strategies and solutions. Here, we advance, for cardiac myxoma, the hypothesis of an origin from cardiac neural crest cells and we attempt to support it by an integrated discussion of current knowledge about embryological characteristics of neural crest cells and most recent studies focusing cardiac myxomas. We discuss the relationship between the basic plasticity of cardiac neural crest cells and some typical mutations arising in neoplastic lesions as well as the expression of typical cell markers of neural crests derivatives. Dysfunctions in proliferative and migratory programs, focused in other studies, are evaluated in the context of the topological and histopathological characteristics of cardiac myxomas.
在心脏黏液瘤中，恶性转化过程中选择偶然的基因突变并导致增殖失控，对肿瘤质量的生长速度没有如此剧烈的影响，但病变的特定位置常常对健康构成高风险。为了对癌细胞进行准确的分析，确定恶性细胞的胚胎起源及其最初的分化状态非常重要，尤其是在治疗策略和解决方案方面。在这里，我们提出心脏黏液瘤起源于心脏神经嵴细胞的假说，并试图通过综合讨论神经嵴细胞的胚胎特征和最近关于心脏黏液瘤的研究来支持这一假说。我们讨论了心脏神经嵴细胞的基本可塑性与肿瘤病变中出现的一些典型突变之间的关系，以及神经嵴细胞衍生物的典型细胞标志物的表达。在心脏黏液瘤的拓扑和组织病理学特征的背景下，评估了其他研究中聚焦的增殖和迁移程序的功能障碍。
