Chen Qunlin, Xia Yunman, Zhuang Kaixiang, Wu Xinran, Liu Guangyuan, Qiu Jiang
School of Mathematics and Statistics, Southwest University, Chongqing, China.
Key Laboratory of Cognition and Personality, Ministry of Education, Chongqing, China.
Aging (Albany NY). 2019 Nov 21;11(22):10100-10115. doi: 10.18632/aging.102421.
Normal aging is known to be accompanied by decreased segregation across the whole-brain functional network, which is associated with cognitive decline. Although compelling evidence supports reduced segregation and increased integration in whole-brain functional connectivity with aging, the age effect on the reorganization of large-scale functional networks at the hemispheric level remains unclear. Here, we aimed to examine age-related differences in inter-hemispheric interactions and intra-hemispheric integration by using resting-state functional MRI data of a healthy adult lifespan sample. The results showed that age-related decreases in inter-hemispheric integration were found in entire functional networks in both hemispheres, except for the sensorimotor network (SMN) and posterior default mode network (DMN). Specifically, aging was accompanied by increasing inter-hemispheric segregation in the left frontoparietal network (FPN) and left ventral attention network (VAN), as well as right-brain networks located in the auditory network (AN), visual network (VN), and temporal parts of the DMN. Moreover, aging was associated with increasing intra-hemispheric integration within the bilateral VN and posterior DMN while decreasing intra-hemispheric integration within the right VAN. These remarkable changes with aging confirm that there are dynamic interactions between functional networks across the lifespan and provide a means of investigating the mechanisms of cognitive aging.
众所周知，正常衰老伴随着全脑功能网络中隔离的减少，这与认知能力下降有关。尽管有令人信服的证据支持随着衰老全脑功能连接中隔离减少和整合增加，但年龄对半球水平大规模功能网络重组的影响仍不清楚。在这里，我们旨在通过使用健康成人寿命样本的静息态功能磁共振成像数据来研究半球间相互作用和半球内整合的年龄相关差异。结果表明，除感觉运动网络（SMN）和后默认模式网络（DMN）外，两个半球的整个功能网络中均发现与年龄相关的半球间整合减少。具体而言，衰老伴随着左额顶网络（FPN）和左腹侧注意网络（VAN）以及位于听觉网络（AN）、视觉网络（VN）和DMN颞叶部分的右脑网络中半球间隔离的增加。此外，衰老与双侧VN和后DMN内半球内整合增加相关，而与右VAN内半球内整合减少相关。这些随衰老而出现的显著变化证实了整个生命周期中功能网络之间存在动态相互作用，并为研究认知衰老机制提供了一种方法。
