Romanov Yu A, Vtorushina V V, Dugina T N, Romanov A Yu, Petrova N V
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia.
CryoCenter Cord Blood Bank, Moscow, Russia.
Bull Exp Biol Med. 2019 Nov;168(1):173-177. doi: 10.1007/s10517-019-04670-2. Epub 2019 Nov 25.
The concentrations of cytokines and growth factors in human umbilical cord blood serum and plasma samples were measured by multiplex analysis. It was found that in comparison with peripheral blood serum of adult donors, umbilical cord blood serum and plasma contain significantly higher concentrations of the most studied molecules including IL-4, 5, 6, 7, 10 and 15, MCP-1, SCF, and SDF, as well as growth factors directly involved in the processes of regeneration (G-CSF, HGF, PDGF-BB, and VEGF). Thus, umbilical cord blood plasma and especially serum are a rich source of cytokines and growth factors with anti-inflammatory, anti-apoptotic, and angiogenic effects and can be used in various fields of regenerative medicine.
通过多重分析测定了人脐带血血清和血浆样本中细胞因子和生长因子的浓度。结果发现，与成年供体的外周血血清相比，脐带血血清和血浆中多种研究较多的分子浓度显著更高，包括白细胞介素-4、5、6、7、10和15、单核细胞趋化蛋白-1、干细胞因子、基质细胞衍生因子，以及直接参与再生过程的生长因子（粒细胞集落刺激因子、肝细胞生长因子、血小板衍生生长因子-BB和血管内皮生长因子）。因此，脐带血血浆尤其是血清是具有抗炎、抗凋亡和血管生成作用的细胞因子和生长因子的丰富来源，可用于再生医学的各个领域。
