Department of Biology, College of Natural Science, Chosun University, Gwangju, Republic of Korea.
Department of Life Science, BK21-Plus Research Team for Bioactive Control Technology, Chosun University, Gwangju, Republic of Korea.
In Vivo. 2021 Mar-Apr;35(2):699-705. doi: 10.21873/invivo.12310.
Regenerative medicine is a branch of medicine that incorporates tissue-engineering, biomaterials, and cell therapy approaches to replace or repair damaged cells and tissues. Umbilical cord serum (UCS) is an important liquid component of cord blood, which has a reliable source of innumerable growth factors and biologically active molecules. Usually, serum can be prepared from different sources of blood. In therapeutic application, cord serum can be prepared and used in the form of eye drops for the treatment of severe dry eye diseases, ocular burns, glaucoma, persistent corneal epithelial defects and neurotrophic keratitis. In addition, cord serum combined with synthetic bio scaffold materials is used to regenerate different types of tissues including tympanic membrane regeneration, bone regeneration and nerve regeneration. Absence of animal origin viruses and bacteria, lack of xenoproteins and cost-effective features make cord serum a feasible choice as replacement of fetal bovine serum in cell culture techniques. Thus, this review emphasizes the role of cord serum in regenerative therapy and clinical uses.
再生医学是医学的一个分支，它结合了组织工程、生物材料和细胞治疗方法，以替代或修复受损的细胞和组织。脐带血清（UCS）是脐带血的重要液体成分，它有无数生长因子和生物活性分子的可靠来源。通常，血清可以从不同来源的血液中制备。在治疗应用中，脐带血清可以制备并以眼药水的形式用于治疗严重干眼症、眼部烧伤、青光眼、持续性角膜上皮缺损和神经营养性角膜炎。此外，脐带血清与合成生物支架材料结合，用于再生不同类型的组织，包括鼓膜再生、骨再生和神经再生。无动物源病毒和细菌、缺乏异源蛋白以及具有成本效益的特点，使得脐带血清成为细胞培养技术中替代胎牛血清的可行选择。因此，本综述强调了脐带血清在再生治疗和临床应用中的作用。
