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从[植物名称]种子中分离出的新型五环三萜可改善链脲佐菌素诱导的糖尿病大鼠的糖尿病状况。 （原文中ameliorates前缺少植物名称，翻译时根据语境补充为[植物名称]，以便完整准确传达意思）

Novel pentacyclic triterpene isolated from seeds of ameliorates diabetes in streptozotocin induced diabetic rats.

作者信息

Ahmed Danish, Khan Mohd Ibrahim, Sharma Manju, Khan Mohd Faiyaz

机构信息

Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Allahabad, Uttar Pradesh, INDIA.

Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India.

出版信息

Interdiscip Toxicol. 2018 Dec;11(4):275-288. doi: 10.2478/intox-2018-0027. Epub 2019 Oct 18.

DOI:10.2478/intox-2018-0027
PMID:31762679
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6853018/
Abstract

The present research was carried out to study the effect of 2β-hydroxybetulinic acid 3β-oleiate (HBAO), a novel compound isolated from the seeds of on glycemic control, antioxidant status and histopathological morphological alterations in the liver, pancreas, kidney and heart in streptozotocin induced type-2 diabetes in rats. HBAO was isolated from the seeds of according to Lee. Isolation of the active principle HBAO was performed for the first time. To date there are no reports on the isolation and evaluation of 2β-hydroxybetulinic acid 3β-oleiate (HBAO) from Assessment of different biochemical parameters like the effect of HBAO on glycemic control, plasma insulin, glycosylated hemoglobin, hepatic glucose-6-phosphate dehydrogenase, glucose-6-phosphatase and fructose-1-6-biphosphatase, hepatic hexokinase, lipid profile, antioxidant marker and histopathology of pancreas, liver and kidney examination was done at the end of the experimentation, i.e. on day 45. HBAO exhibited remarkable improvement in glycemic control, lipid levels, plasma insulin, glycogenic liver enzymes and antioxidant activity in diabetic rats, along with progressive enhancement of distortive histopathological morphology of liver, pancreas and kidney. The results strongly suggest that HBAO could be a potential therapeutic agent in diabetes.

摘要

本研究旨在探讨从[植物名称]种子中分离出的新型化合物2β-羟基桦木酸3β-油酸酯（HBAO）对链脲佐菌素诱导的大鼠2型糖尿病血糖控制、抗氧化状态以及肝脏、胰腺、肾脏和心脏组织病理学形态改变的影响。HBAO是根据Lee的方法从[植物名称]种子中分离得到的。首次进行了活性成分HBAO的分离。迄今为止，尚无关于从[植物名称]中分离和评估2β-羟基桦木酸3β-油酸酯（HBAO）的报道。在实验结束时，即第45天，对不同生化参数进行了评估，如HBAO对血糖控制、血浆胰岛素、糖化血红蛋白、肝葡萄糖-6-磷酸脱氢酶、葡萄糖-6-磷酸酶和果糖-1,6-二磷酸酶、肝己糖激酶、血脂谱、抗氧化标志物的影响，以及胰腺、肝脏和肾脏的组织病理学检查。HBAO在糖尿病大鼠的血糖控制、血脂水平、血浆胰岛素、糖原性肝酶和抗氧化活性方面表现出显著改善，同时肝脏、胰腺和肾脏的扭曲组织病理学形态逐渐改善。结果强烈表明，HBAO可能是一种潜在的糖尿病治疗药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33bf/6853018/2d4766000283/ITX-11-275-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33bf/6853018/78c4d275caf9/ITX-11-275-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33bf/6853018/9f741187f0ad/ITX-11-275-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33bf/6853018/0fbcc8999264/ITX-11-275-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33bf/6853018/aea0e18f877e/ITX-11-275-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33bf/6853018/7ff44db18a23/ITX-11-275-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33bf/6853018/690d54408143/ITX-11-275-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33bf/6853018/e1551c324529/ITX-11-275-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33bf/6853018/7f019954120b/ITX-11-275-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33bf/6853018/f2fde05686c2/ITX-11-275-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33bf/6853018/2d4766000283/ITX-11-275-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33bf/6853018/78c4d275caf9/ITX-11-275-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33bf/6853018/9f741187f0ad/ITX-11-275-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33bf/6853018/0fbcc8999264/ITX-11-275-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33bf/6853018/aea0e18f877e/ITX-11-275-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33bf/6853018/7ff44db18a23/ITX-11-275-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33bf/6853018/690d54408143/ITX-11-275-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33bf/6853018/e1551c324529/ITX-11-275-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33bf/6853018/7f019954120b/ITX-11-275-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33bf/6853018/f2fde05686c2/ITX-11-275-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33bf/6853018/2d4766000283/ITX-11-275-g010.jpg

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